Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2644334..2644659 Replicon chromosome
Accession NZ_AP024625
Organism Bacillus subtilis strain BEST3109

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag BsBEST3145_RS13865 Protein ID WP_004398662.1
Coordinates 2644334..2644513 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2644437..2644659 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BsBEST3145_RS13855 (2643560) 2643560..2643697 - 138 WP_003229934.1 hypothetical protein -
BsBEST3145_RS13860 (2643739) 2643739..2644188 - 450 WP_003229933.1 phage portal protein -
BsBEST3145_RS13865 (2644334) 2644334..2644513 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2644437) 2644437..2644659 - 223 NuclAT_0 - Antitoxin
- (2644437) 2644437..2644659 - 223 NuclAT_0 - Antitoxin
- (2644437) 2644437..2644659 - 223 NuclAT_0 - Antitoxin
- (2644437) 2644437..2644659 - 223 NuclAT_0 - Antitoxin
BsBEST3145_RS13870 (2644893) 2644893..2644982 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
BsBEST3145_RS13875 (2645236) 2645236..2645679 - 444 WP_003229930.1 phage tail tube protein -
BsBEST3145_RS13880 (2645682) 2645682..2647082 - 1401 WP_003229929.1 phage tail sheath family protein -
BsBEST3145_RS13885 (2647083) 2647083..2647274 - 192 WP_010886574.1 hypothetical protein -
BsBEST3145_RS13890 (2647271) 2647271..2647708 - 438 WP_003229927.1 hypothetical protein -
BsBEST3145_RS13895 (2647721) 2647721..2648224 - 504 WP_003246050.1 HK97 gp10 family phage protein -
BsBEST3145_RS13900 (2648221) 2648221..2648583 - 363 WP_003229925.1 YqbH/XkdH family protein -
BsBEST3145_RS13905 (2648580) 2648580..2648975 - 396 WP_004398566.1 DUF3199 family protein -
BsBEST3145_RS13910 (2648979) 2648979..2649290 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2613847..2665337 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39072 WP_004398662.1 NZ_AP024625:2644334-2644513 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39072 NZ_AP024625:2644334-2644513 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39072 NZ_AP024625:c2644659-2644437 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References