Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-ratA/- |
| Location | 2677830..2678155 | Replicon | chromosome |
| Accession | NZ_CP082924 | ||
| Organism | Bacillus subtilis strain FJAT-4 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | P54373 |
| Locus tag | K8U58_RS14090 | Protein ID | WP_004398662.1 |
| Coordinates | 2677830..2678009 (+) | Length | 60 a.a. |
Antitoxin (RNA)
| Gene name | ratA | ||
| Locus tag | - | ||
| Coordinates | 2677933..2678155 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8U58_RS14080 (2677056) | 2677056..2677193 | - | 138 | WP_003229934.1 | hypothetical protein | - |
| K8U58_RS14085 (2677235) | 2677235..2677684 | - | 450 | WP_003229933.1 | phage portal protein | - |
| K8U58_RS14090 (2677830) | 2677830..2678009 | + | 180 | WP_004398662.1 | type I toxin-antitoxin system toxin TxpA | Toxin |
| - (2677933) | 2677933..2678155 | - | 223 | NuclAT_0 | - | Antitoxin |
| - (2677933) | 2677933..2678155 | - | 223 | NuclAT_0 | - | Antitoxin |
| - (2677933) | 2677933..2678155 | - | 223 | NuclAT_0 | - | Antitoxin |
| - (2677933) | 2677933..2678155 | - | 223 | NuclAT_0 | - | Antitoxin |
| K8U58_RS14095 (2678389) | 2678389..2678478 | + | 90 | WP_075058862.1 | type I toxin-antitoxin system toxin BsrH | - |
| K8U58_RS14100 (2678732) | 2678732..2679175 | - | 444 | WP_003229930.1 | phage tail tube protein | - |
| K8U58_RS14105 (2679178) | 2679178..2680578 | - | 1401 | WP_003229929.1 | phage tail sheath family protein | - |
| K8U58_RS14110 (2680579) | 2680579..2680770 | - | 192 | WP_010886574.1 | hypothetical protein | - |
| K8U58_RS14115 (2680767) | 2680767..2681204 | - | 438 | WP_003229927.1 | hypothetical protein | - |
| K8U58_RS14120 (2681217) | 2681217..2681720 | - | 504 | WP_003246050.1 | HK97 gp10 family phage protein | - |
| K8U58_RS14125 (2681717) | 2681717..2682079 | - | 363 | WP_003229925.1 | YqbH/XkdH family protein | - |
| K8U58_RS14130 (2682076) | 2682076..2682471 | - | 396 | WP_004398566.1 | DUF3199 family protein | - |
| K8U58_RS14135 (2682475) | 2682475..2682786 | - | 312 | WP_003229923.1 | YqbF domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2647343..2698833 | 51490 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6739.19 Da Isoelectric Point: 8.0370
>T215613 WP_004398662.1 NZ_CP082924:2677830-2678009 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG
Download Length: 180 bp
>T215613 NZ_CP110851:39743-40639 [Lactococcus lactis]
ATGAAAAATACAAGGTTAAAGGATTTAATTGCAACAAGAAATGATGATACTGGAATTGAAAATTATAGAATAAGATATGC
AACTGAAAGATTCTTAACAAGGCTTTCGGCAAGTCAATATAAGGAAAAATTTGCTTTAAAAGGAGGTTTTTTAATTAGTG
TCACCTATAACTTGAGTCAGAGGACTACTAAGGATTTAGATACAGCTCTGATAGACTTTAAAAGTGATGCACAGTCTATT
GAACGGGTAATTACTGAAATATGTAATATAGATTTAGAAGACCAAGTGCTTTTTAAATTAAAGGAACTTACAAGCAGTCA
AGATATGAGAATATATCCTGGGTACAGAGCTAAACTTAAGATGATGTTTCCTGATGGAAATACAAGGATAGACTTTGATC
TTGATATTGGAGTAGGAGATAGGATAACCCCAGAGGCTAAGAAAATAAAAATACCTCTAATATTTAATGAAGTAAAAGGT
GTAGAGAAACAGATAGAAGTATTAGCTTATCCAAAGGAAACTATTCAGGCAGAAAAATTAGAGACAATTCTCACTCGGGG
GAAAGTAAATACTAGAATGAAAGATTATTACGATTTTCATTTGCTTTTGACTGATCAAGAAAATAGTAATAGTATAAGTT
TTTATTGTGCTTTTAAAAATACTTGGGAATTTAGAAACCCAACTCAATTAATTGATGAAGAACTGTTTGAAGATTGGCTC
TTTATTTTAGATGAGATACTTGAATCAAAAGAATTGAAAGAAAAGTATTGGCCAAACTATATTAAAGATAGAAATTATGC
TAAACATCTAAACATAGATGATATCATTTCAGAAATTAAAGAATTTGTTAGTAAATTAAAAGAAGAATATATAAAGGAGA
ATATGTCTAGAAATTAA
ATGAAAAATACAAGGTTAAAGGATTTAATTGCAACAAGAAATGATGATACTGGAATTGAAAATTATAGAATAAGATATGC
AACTGAAAGATTCTTAACAAGGCTTTCGGCAAGTCAATATAAGGAAAAATTTGCTTTAAAAGGAGGTTTTTTAATTAGTG
TCACCTATAACTTGAGTCAGAGGACTACTAAGGATTTAGATACAGCTCTGATAGACTTTAAAAGTGATGCACAGTCTATT
GAACGGGTAATTACTGAAATATGTAATATAGATTTAGAAGACCAAGTGCTTTTTAAATTAAAGGAACTTACAAGCAGTCA
AGATATGAGAATATATCCTGGGTACAGAGCTAAACTTAAGATGATGTTTCCTGATGGAAATACAAGGATAGACTTTGATC
TTGATATTGGAGTAGGAGATAGGATAACCCCAGAGGCTAAGAAAATAAAAATACCTCTAATATTTAATGAAGTAAAAGGT
GTAGAGAAACAGATAGAAGTATTAGCTTATCCAAAGGAAACTATTCAGGCAGAAAAATTAGAGACAATTCTCACTCGGGG
GAAAGTAAATACTAGAATGAAAGATTATTACGATTTTCATTTGCTTTTGACTGATCAAGAAAATAGTAATAGTATAAGTT
TTTATTGTGCTTTTAAAAATACTTGGGAATTTAGAAACCCAACTCAATTAATTGATGAAGAACTGTTTGAAGATTGGCTC
TTTATTTTAGATGAGATACTTGAATCAAAAGAATTGAAAGAAAAGTATTGGCCAAACTATATTAAAGATAGAAATTATGC
TAAACATCTAAACATAGATGATATCATTTCAGAAATTAAAGAATTTGTTAGTAAATTAAAAGAAGAATATATAAAGGAGA
ATATGTCTAGAAATTAA
Antitoxin
Download Length: 223 bp
>AT215613 NZ_CP082924:c2678155-2677933 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
