Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2677857..2678182 Replicon chromosome
Accession NZ_CP075344
Organism Bacillus subtilis subsp. subtilis strain A1 - Midalam

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag KIL00_RS14065 Protein ID WP_004398662.1
Coordinates 2677857..2678036 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2677960..2678182 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIL00_RS14055 (2677083) 2677083..2677220 - 138 WP_003229934.1 hypothetical protein -
KIL00_RS14060 (2677262) 2677262..2677711 - 450 WP_213783413.1 phage portal protein -
KIL00_RS14065 (2677857) 2677857..2678036 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2677960) 2677960..2678182 - 223 NuclAT_0 - Antitoxin
- (2677960) 2677960..2678182 - 223 NuclAT_0 - Antitoxin
- (2677960) 2677960..2678182 - 223 NuclAT_0 - Antitoxin
- (2677960) 2677960..2678182 - 223 NuclAT_0 - Antitoxin
KIL00_RS14070 (2678416) 2678416..2678505 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
KIL00_RS14075 (2678759) 2678759..2679202 - 444 WP_213783414.1 phage tail tube protein -
KIL00_RS14080 (2679205) 2679205..2680605 - 1401 WP_003229929.1 phage tail sheath family protein -
KIL00_RS14085 (2680606) 2680606..2680797 - 192 WP_010886574.1 hypothetical protein -
KIL00_RS14090 (2680794) 2680794..2681231 - 438 WP_003229927.1 hypothetical protein -
KIL00_RS14095 (2681244) 2681244..2681747 - 504 WP_003246050.1 HK97 gp10 family phage protein -
KIL00_RS14100 (2681744) 2681744..2682106 - 363 WP_003229925.1 YqbH/XkdH family protein -
KIL00_RS14105 (2682103) 2682103..2682498 - 396 WP_004398566.1 DUF3199 family protein -
KIL00_RS14110 (2682502) 2682502..2682813 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2647371..2698858 51487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T203485 WP_004398662.1 NZ_CP075344:2677857-2678036 [Bacillus subtilis subsp. subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T203485 NZ_CP100102:c1504219-1503902 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 223 bp

>AT203485 NZ_CP075344:c2678182-2677960 [Bacillus subtilis subsp. subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References