Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2591278..2591603 Replicon chromosome
Accession NZ_CP064093
Organism Bacillus subtilis strain N1282-4at

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag IRJ24_RS13490 Protein ID WP_004398662.1
Coordinates 2591424..2591603 (-) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2591278..2591500 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ24_RS13445 (2586647) 2586647..2586958 + 312 WP_003229923.1 YqbF domain-containing protein -
IRJ24_RS13450 (2586962) 2586962..2587357 + 396 WP_004398566.1 DUF3199 family protein -
IRJ24_RS13455 (2587354) 2587354..2587716 + 363 WP_003229925.1 YqbH/XkdH family protein -
IRJ24_RS13460 (2587713) 2587713..2588216 + 504 WP_003246050.1 HK97 gp10 family phage protein -
IRJ24_RS13465 (2588229) 2588229..2588666 + 438 WP_003229927.1 hypothetical protein -
IRJ24_RS13470 (2588663) 2588663..2588854 + 192 WP_010886574.1 hypothetical protein -
IRJ24_RS13475 (2588855) 2588855..2590255 + 1401 WP_003229929.1 phage tail sheath family protein -
IRJ24_RS13480 (2590258) 2590258..2590701 + 444 WP_003229930.1 phage tail tube protein -
IRJ24_RS13485 (2590955) 2590955..2591044 - 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
- (2591278) 2591278..2591500 + 223 NuclAT_0 - Antitoxin
- (2591278) 2591278..2591500 + 223 NuclAT_0 - Antitoxin
- (2591278) 2591278..2591500 + 223 NuclAT_0 - Antitoxin
- (2591278) 2591278..2591500 + 223 NuclAT_0 - Antitoxin
IRJ24_RS13490 (2591424) 2591424..2591603 - 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
IRJ24_RS13495 (2591749) 2591749..2592198 + 450 WP_003229933.1 phage portal protein -
IRJ24_RS13500 (2592240) 2592240..2592377 + 138 WP_003229934.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2570600..2633747 63147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T180031 WP_004398662.1 NZ_CP064093:c2591603-2591424 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T180031 NZ_CP085056:300308-300538 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 223 bp

>AT180031 NZ_CP064093:2591278-2591500 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References