Detailed information of TA system TA166398

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2678246..2678571
• Replicon: chromosome
• Accession: NZ_CP058242
• Organism: Bacillus subtilis strain SP1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: HWV68_RS14040
• Protein ID: WP_004398662.1
• Coordinates: 2678246..2678425 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2678349..2678571 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWV68_RS14030	2677472..2677609	-	138	WP_003229934.1	hypothetical protein	-
HWV68_RS14035	2677651..2678100	-	450	WP_003229933.1	phage portal protein	-
HWV68_RS14040	2678246..2678425	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2678349..2678571	-	223	NuclAT_0	-	Antitoxin
-	2678349..2678571	-	223	NuclAT_0	-	Antitoxin
-	2678349..2678571	-	223	NuclAT_0	-	Antitoxin
-	2678349..2678571	-	223	NuclAT_0	-	Antitoxin
HWV68_RS14045	2678805..2678894	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
HWV68_RS14050	2679148..2679591	-	444	WP_003229930.1	phage tail tube protein	-
HWV68_RS14055	2679594..2680994	-	1401	WP_003229929.1	phage tail sheath family protein	-
HWV68_RS14060	2680995..2681186	-	192	WP_010886574.1	hypothetical protein	-
HWV68_RS14065	2681183..2681620	-	438	WP_003229927.1	hypothetical protein	-
HWV68_RS14070	2681633..2682136	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
HWV68_RS14075	2682133..2682495	-	363	WP_003229925.1	YqbH/XkdH family protein	-
HWV68_RS14080	2682492..2682887	-	396	WP_004398566.1	DUF3199 family protein	-
HWV68_RS14085	2682891..2683202	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000964 Bacillus subtilis subsp. subtilis str. 168 Prophage TA006322, TA010201, TA020260 2645490..2699243 0.001	inside	Prophage	-	-	2647759..2699249	51490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T166398 WP_004398662.1 NZ_CP058242:2678246-2678425 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T166398 NZ_CP074144:c12507-12175 [Serratia sp. JSRIV002]
ATGGTTAAAGGTTATGTTCCTGACGCCGGTGATATTGTCTGGTTAGAGTTTGATCCCCAGGCAGGGCATGAACAAGCGGG
CCATCGCCCTGCTTTAGTGCTCAGTCCCGCTGTATACAACGGGCGGATTGGGTTAATGCTGTGCTGCCCGATGACAACCA
AAATCAAAGGGTATCCTTTTGAAGTCATTGTCCCTGGTGAACGTGAGAGTGCAGTCCTTGCCGATCAAGTTAAGAGCCTG
GATTGGAAAGAACGTAATGCAACAAAAAAGGGACAGGTACCTGCGTCGGTACTGTCGGATGTTCGTGCAAAGGCAAAAGC
CTTAATAGGGTAA

Antitoxin

Nucleotide

• Length: 223 bp

>AT166398 NZ_CP058242:c2678571-2678349 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin