Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2680044..2680369 Replicon chromosome
Accession NZ_CP112873
Organism Bacillus subtilis strain O4

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag ORF34_RS14125 Protein ID WP_004398662.1
Coordinates 2680044..2680223 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2680147..2680369 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORF34_RS14115 (2679270) 2679270..2679407 - 138 WP_003229934.1 hypothetical protein -
ORF34_RS14120 (2679449) 2679449..2679898 - 450 WP_003229933.1 phage portal protein -
ORF34_RS14125 (2680044) 2680044..2680223 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2680147) 2680147..2680369 - 223 NuclAT_0 - Antitoxin
- (2680147) 2680147..2680369 - 223 NuclAT_0 - Antitoxin
- (2680147) 2680147..2680369 - 223 NuclAT_0 - Antitoxin
- (2680147) 2680147..2680369 - 223 NuclAT_0 - Antitoxin
ORF34_RS14130 (2680603) 2680603..2680692 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
ORF34_RS14135 (2680946) 2680946..2681389 - 444 WP_003229930.1 phage tail tube protein -
ORF34_RS14140 (2681392) 2681392..2682792 - 1401 WP_003229929.1 phage tail sheath family protein -
ORF34_RS14145 (2682793) 2682793..2682984 - 192 WP_010886574.1 hypothetical protein -
ORF34_RS14150 (2682981) 2682981..2683418 - 438 WP_003229927.1 hypothetical protein -
ORF34_RS14155 (2683431) 2683431..2683934 - 504 WP_003246050.1 HK97 gp10 family phage protein -
ORF34_RS14160 (2683931) 2683931..2684293 - 363 WP_003229925.1 YqbH/XkdH family protein -
ORF34_RS14165 (2684290) 2684290..2684685 - 396 WP_004398566.1 DUF3199 family protein -
ORF34_RS14170 (2684689) 2684689..2685000 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2647294..2719980 72686
inside Prophage - - 2649557..2704908 55351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T264916 WP_004398662.1 NZ_CP112873:2680044-2680223 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

Antitoxin


Download         Length: 223 bp

>AT264916 NZ_CP112873:c2680369-2680147 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References