Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2076780..2077105 Replicon chromosome
Accession NZ_CP093067
Organism Bacillus subtilis strain ATC-3

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag MM522_RS10645 Protein ID WP_004398662.1
Coordinates 2076780..2076959 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2076883..2077105 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM522_RS10635 (2076006) 2076006..2076143 - 138 WP_021480099.1 hypothetical protein -
MM522_RS10640 (2076185) 2076185..2076634 - 450 WP_032722171.1 phage portal protein -
MM522_RS10645 (2076780) 2076780..2076959 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2076883) 2076883..2077105 - 223 NuclAT_0 - Antitoxin
- (2076883) 2076883..2077105 - 223 NuclAT_0 - Antitoxin
- (2076883) 2076883..2077105 - 223 NuclAT_0 - Antitoxin
- (2076883) 2076883..2077105 - 223 NuclAT_0 - Antitoxin
MM522_RS10650 (2077339) 2077339..2077428 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
MM522_RS10655 (2077682) 2077682..2078125 - 444 WP_003229930.1 phage tail tube protein -
MM522_RS10660 (2078128) 2078128..2079528 - 1401 WP_003229929.1 phage tail sheath family protein -
MM522_RS10665 (2079529) 2079529..2079720 - 192 WP_010886574.1 hypothetical protein -
MM522_RS10670 (2079717) 2079717..2080154 - 438 WP_003229927.1 hypothetical protein -
MM522_RS10675 (2080167) 2080167..2080670 - 504 WP_003246050.1 HK97 gp10 family phage protein -
MM522_RS10680 (2080667) 2080667..2081029 - 363 WP_003229925.1 YqbH/XkdH family protein -
MM522_RS10685 (2081026) 2081026..2081421 - 396 WP_004398566.1 DUF3199 family protein -
MM522_RS10690 (2081425) 2081425..2081736 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2046290..2097783 51493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T237655 WP_004398662.1 NZ_CP093067:2076780-2076959 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T237655 NZ_LR882499:364727-365029 [Mycobacterium tuberculosis variant microti OV254]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 223 bp

>AT237655 NZ_CP093067:c2077105-2076883 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References