Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2524047..2524372 Replicon chromosome
Accession NZ_CP113256
Organism Bacillus subtilis strain K1

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag ORP33_RS13000 Protein ID WP_004398662.1
Coordinates 2524047..2524226 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2524150..2524372 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORP33_RS12990 (2523273) 2523273..2523410 - 138 WP_021480099.1 hypothetical protein -
ORP33_RS12995 (2523452) 2523452..2523901 - 450 WP_032722171.1 phage portal protein -
ORP33_RS13000 (2524047) 2524047..2524226 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2524150) 2524150..2524372 - 223 NuclAT_0 - Antitoxin
- (2524150) 2524150..2524372 - 223 NuclAT_0 - Antitoxin
- (2524150) 2524150..2524372 - 223 NuclAT_0 - Antitoxin
- (2524150) 2524150..2524372 - 223 NuclAT_0 - Antitoxin
ORP33_RS13005 (2524606) 2524606..2524695 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
ORP33_RS13010 (2524949) 2524949..2525392 - 444 WP_003229930.1 phage tail tube protein -
ORP33_RS13015 (2525395) 2525395..2526795 - 1401 WP_003229929.1 phage tail sheath family protein -
ORP33_RS13020 (2526796) 2526796..2526987 - 192 WP_010886574.1 hypothetical protein -
ORP33_RS13025 (2526984) 2526984..2527421 - 438 WP_003229927.1 hypothetical protein -
ORP33_RS13030 (2527434) 2527434..2527937 - 504 WP_003246050.1 HK97 gp10 family phage protein -
ORP33_RS13035 (2527934) 2527934..2528296 - 363 WP_003229925.1 YqbH/XkdH family protein -
ORP33_RS13040 (2528293) 2528293..2528688 - 396 WP_004398566.1 DUF3199 family protein -
ORP33_RS13045 (2528692) 2528692..2529003 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2491294..2547562 56268
- inside Prophage - - 2493557..2560816 67259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T265662 WP_004398662.1 NZ_CP113256:2524047-2524226 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

Antitoxin


Download         Length: 223 bp

>AT265662 NZ_CP113256:c2524372-2524150 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References