Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2650453..2650778 Replicon chromosome
Accession NZ_AP024627
Organism Bacillus subtilis strain BEST3136

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6J86_RS13870 Protein ID WP_004398662.1
Coordinates 2650453..2650632 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2650556..2650778 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J86_RS13860 (2649679) 2649679..2649816 - 138 WP_003229934.1 hypothetical protein -
K6J86_RS13865 (2649858) 2649858..2650307 - 450 WP_003229933.1 phage portal protein -
K6J86_RS13870 (2650453) 2650453..2650632 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2650556) 2650556..2650778 - 223 NuclAT_0 - Antitoxin
- (2650556) 2650556..2650778 - 223 NuclAT_0 - Antitoxin
- (2650556) 2650556..2650778 - 223 NuclAT_0 - Antitoxin
- (2650556) 2650556..2650778 - 223 NuclAT_0 - Antitoxin
K6J86_RS13875 (2651012) 2651012..2651101 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6J86_RS13880 (2651355) 2651355..2651798 - 444 WP_003229930.1 phage tail tube protein -
K6J86_RS13885 (2651801) 2651801..2653201 - 1401 WP_003229929.1 phage tail sheath family protein -
K6J86_RS13890 (2653202) 2653202..2653393 - 192 WP_010886574.1 hypothetical protein -
K6J86_RS13895 (2653390) 2653390..2653827 - 438 WP_003229927.1 hypothetical protein -
K6J86_RS13900 (2653840) 2653840..2654343 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6J86_RS13905 (2654340) 2654340..2654702 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6J86_RS13910 (2654699) 2654699..2655094 - 396 WP_004398566.1 DUF3199 family protein -
K6J86_RS13915 (2655098) 2655098..2655409 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2625206..2675317 50111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39118 WP_004398662.1 NZ_AP024627:2650453-2650632 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39118 NZ_AP024627:2650453-2650632 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39118 NZ_AP024627:c2650778-2650556 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References