Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2516090..2516415 Replicon chromosome
Accession NZ_CP035191
Organism Bacillus subtilis strain SRCM104011

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag EQJ84_RS12955 Protein ID WP_004398662.1
Coordinates 2516090..2516269 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2516193..2516415 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQJ84_RS12945 2515316..2515453 - 138 WP_021480099.1 hypothetical protein -
EQJ84_RS12950 2515495..2515944 - 450 WP_032722171.1 phage portal protein -
EQJ84_RS12955 2516090..2516269 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2516193..2516415 - 223 NuclAT_0 - Antitoxin
- 2516193..2516415 - 223 NuclAT_0 - Antitoxin
- 2516193..2516415 - 223 NuclAT_0 - Antitoxin
- 2516193..2516415 - 223 NuclAT_0 - Antitoxin
EQJ84_RS12960 2516649..2516738 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
EQJ84_RS12965 2516992..2517435 - 444 WP_003229930.1 phage tail tube protein -
EQJ84_RS12970 2517438..2518838 - 1401 WP_003229929.1 phage tail sheath family protein -
EQJ84_RS12975 2518839..2518988 - 150 WP_128484481.1 hypothetical protein -
EQJ84_RS12980 2519026..2519463 - 438 WP_003229927.1 hypothetical protein -
EQJ84_RS12985 2519476..2519979 - 504 WP_003246050.1 HK97 gp10 family phage protein -
EQJ84_RS12990 2519976..2520338 - 363 WP_003229925.1 YqbH/XkdH family protein -
EQJ84_RS12995 2520335..2520730 - 396 WP_004398566.1 DUF3199 family protein -
EQJ84_RS13000 2520734..2521045 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2485599..2537092 51493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T117306 WP_004398662.1 NZ_CP035191:2516090-2516269 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T117306 NZ_CP035191:2516090-2516269 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT117306 NZ_CP035191:c2516415-2516193 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References