Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2646839..2647164 Replicon chromosome
Accession NZ_AP024623
Organism Bacillus subtilis strain BEST3102

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6J99_RS13870 Protein ID WP_004398662.1
Coordinates 2646839..2647018 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2646942..2647164 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J99_RS13860 (2646065) 2646065..2646202 - 138 WP_003229934.1 hypothetical protein -
K6J99_RS13865 (2646244) 2646244..2646693 - 450 WP_003229933.1 phage portal protein -
K6J99_RS13870 (2646839) 2646839..2647018 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2646942) 2646942..2647164 - 223 NuclAT_0 - Antitoxin
- (2646942) 2646942..2647164 - 223 NuclAT_0 - Antitoxin
- (2646942) 2646942..2647164 - 223 NuclAT_0 - Antitoxin
- (2646942) 2646942..2647164 - 223 NuclAT_0 - Antitoxin
K6J99_RS13875 (2647398) 2647398..2647487 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6J99_RS13880 (2647741) 2647741..2648184 - 444 WP_003229930.1 phage tail tube protein -
K6J99_RS13885 (2648187) 2648187..2649587 - 1401 WP_003229929.1 phage tail sheath family protein -
K6J99_RS13890 (2649588) 2649588..2649779 - 192 WP_010886574.1 hypothetical protein -
K6J99_RS13895 (2649776) 2649776..2650213 - 438 WP_003229927.1 hypothetical protein -
K6J99_RS13900 (2650226) 2650226..2650729 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6J99_RS13905 (2650726) 2650726..2651088 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6J99_RS13910 (2651085) 2651085..2651480 - 396 WP_004398566.1 DUF3199 family protein -
K6J99_RS13915 (2651484) 2651484..2651795 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2616352..2667842 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39026 WP_004398662.1 NZ_AP024623:2646839-2647018 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39026 NZ_AP024623:2646839-2647018 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39026 NZ_AP024623:c2647164-2646942 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References