Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2644054..2644379 Replicon chromosome
Accession NZ_AP024624
Organism Bacillus subtilis strain BEST3106

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6J91_RS13880 Protein ID WP_004398662.1
Coordinates 2644054..2644233 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2644157..2644379 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J91_RS13870 (2643280) 2643280..2643417 - 138 WP_003229934.1 hypothetical protein -
K6J91_RS13875 (2643459) 2643459..2643908 - 450 WP_003229933.1 phage portal protein -
K6J91_RS13880 (2644054) 2644054..2644233 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2644157) 2644157..2644379 - 223 NuclAT_0 - Antitoxin
- (2644157) 2644157..2644379 - 223 NuclAT_0 - Antitoxin
- (2644157) 2644157..2644379 - 223 NuclAT_0 - Antitoxin
- (2644157) 2644157..2644379 - 223 NuclAT_0 - Antitoxin
K6J91_RS13885 (2644613) 2644613..2644702 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6J91_RS13890 (2644956) 2644956..2645399 - 444 WP_003229930.1 phage tail tube protein -
K6J91_RS13895 (2645402) 2645402..2646802 - 1401 WP_003229929.1 phage tail sheath family protein -
K6J91_RS13900 (2646803) 2646803..2646994 - 192 WP_010886574.1 hypothetical protein -
K6J91_RS13905 (2646991) 2646991..2647428 - 438 WP_003229927.1 hypothetical protein -
K6J91_RS13910 (2647441) 2647441..2647944 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6J91_RS13915 (2647941) 2647941..2648303 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6J91_RS13920 (2648300) 2648300..2648695 - 396 WP_004398566.1 DUF3199 family protein -
K6J91_RS13925 (2648699) 2648699..2649010 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2613567..2665057 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39049 WP_004398662.1 NZ_AP024624:2644054-2644233 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39049 NZ_AP024624:2644054-2644233 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39049 NZ_AP024624:c2644379-2644157 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References