Detailed information of TA system TA183391

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2677841..2678166
• Replicon: chromosome
• Accession: NZ_CP065789
• Organism: Bacillus subtilis strain LBUM979

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: I8N71_RS14065
• Protein ID: WP_004398662.1
• Coordinates: 2677841..2678020 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2677944..2678166 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8N71_RS14055	2677067..2677204	-	138	WP_003229934.1	hypothetical protein	-
I8N71_RS14060	2677246..2677695	-	450	WP_003229933.1	phage portal protein	-
I8N71_RS14065	2677841..2678020	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2677944..2678166	-	223	NuclAT_0	-	Antitoxin
-	2677944..2678166	-	223	NuclAT_0	-	Antitoxin
-	2677944..2678166	-	223	NuclAT_0	-	Antitoxin
-	2677944..2678166	-	223	NuclAT_0	-	Antitoxin
I8N71_RS14070	2678400..2678489	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
I8N71_RS14075	2678743..2679186	-	444	WP_003229930.1	phage tail tube protein	-
I8N71_RS14080	2679189..2680589	-	1401	WP_003229929.1	phage tail sheath family protein	-
I8N71_RS14085	2680590..2680781	-	192	WP_010886574.1	hypothetical protein	-
I8N71_RS14090	2680778..2681215	-	438	WP_003229927.1	hypothetical protein	-
I8N71_RS14095	2681228..2681731	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
I8N71_RS14100	2681728..2682090	-	363	WP_003229925.1	YqbH/XkdH family protein	-
I8N71_RS14105	2682087..2682482	-	396	WP_004398566.1	DUF3199 family protein	-
I8N71_RS14110	2682486..2682797	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000964 Bacillus subtilis subsp. subtilis str. 168 Prophage TA006322, TA010201, TA020260 2645490..2699243 0.001	inside	Prophage	-	-	2647354..2698844	51490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T183391 WP_004398662.1 NZ_CP065789:2677841-2678020 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T183391 NZ_CP086960:14448-14870 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin

Nucleotide

• Length: 223 bp

>AT183391 NZ_CP065789:c2678166-2677944 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin