Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2678003..2678328 Replicon chromosome
Accession NZ_CP010053
Organism Bacillus subtilis strain PS832

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag QX56_RS13500 Protein ID WP_004398662.1
Coordinates 2678003..2678182 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2678106..2678328 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QX56_RS21895 2677229..2677366 - 138 WP_003229934.1 hypothetical protein -
QX56_RS13495 2677408..2677857 - 450 WP_003229933.1 phage portal protein -
QX56_RS13500 2678003..2678182 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2678106..2678328 - 223 NuclAT_0 - Antitoxin
- 2678106..2678328 - 223 NuclAT_0 - Antitoxin
- 2678106..2678328 - 223 NuclAT_0 - Antitoxin
- 2678106..2678328 - 223 NuclAT_0 - Antitoxin
QX56_RS22485 2678562..2678651 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
QX56_RS13505 2678905..2679348 - 444 WP_003229930.1 phage tail tube protein -
QX56_RS13510 2679351..2680751 - 1401 WP_003229929.1 phage tail sheath family protein -
QX56_RS13515 2680752..2680943 - 192 WP_010886574.1 hypothetical protein -
QX56_RS13520 2680940..2681377 - 438 WP_003229927.1 hypothetical protein -
QX56_RS13525 2681390..2681893 - 504 WP_003246050.1 HK97 gp10 family phage protein -
QX56_RS13530 2681890..2682252 - 363 WP_003229925.1 YqbH/XkdH family protein -
QX56_RS13535 2682249..2682644 - 396 WP_004398566.1 DUF3199 family protein -
QX56_RS13540 2682648..2682959 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2647516..2699006 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T50319 WP_004398662.1 NZ_CP010053:2678003-2678182 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T50319 NZ_CP010053:2678003-2678182 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT50319 NZ_CP010053:c2678328-2678106 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References