Detailed information of TA system TA156136

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2791248..2791573
• Replicon: chromosome
• Accession: NZ_CP053102
• Organism: Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: HIR77_RS14805
• Protein ID: WP_004398662.1
• Coordinates: 2791248..2791427 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2791351..2791573 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIR77_RS14795	2790474..2790611	-	138	WP_003229934.1	hypothetical protein	-
HIR77_RS14800	2790653..2791102	-	450	WP_003229933.1	phage portal protein	-
HIR77_RS14805	2791248..2791427	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2791351..2791573	-	223	NuclAT_0	-	Antitoxin
-	2791351..2791573	-	223	NuclAT_0	-	Antitoxin
-	2791351..2791573	-	223	NuclAT_0	-	Antitoxin
-	2791351..2791573	-	223	NuclAT_0	-	Antitoxin
HIR77_RS14810	2791807..2791896	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
HIR77_RS14815	2792150..2792593	-	444	WP_003229930.1	phage tail tube protein	-
HIR77_RS14820	2792596..2793996	-	1401	WP_003229929.1	phage tail sheath family protein	-
HIR77_RS14825	2793997..2794188	-	192	WP_010886574.1	hypothetical protein	-
HIR77_RS14830	2794185..2794622	-	438	WP_003229927.1	hypothetical protein	-
HIR77_RS14835	2794635..2795138	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
HIR77_RS14840	2795135..2795497	-	363	WP_003229925.1	YqbH/XkdH family protein	-
HIR77_RS14845	2795494..2795889	-	396	WP_004398566.1	DUF3199 family protein	-
HIR77_RS14850	2795893..2796204	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000964 Bacillus subtilis subsp. subtilis str. 168 Prophage TA006322, TA010201, TA020260 2645490..2699243 0.005	inside	Prophage	-	-	2766001..2816112	50111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T156136 WP_004398662.1 NZ_CP053102:2791248-2791427 [Bacillus subtilis subsp. subtilis str. 168]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T156136 NZ_CP068828:2595803-2597125 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACTGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Nucleotide

• Length: 223 bp

>AT156136 NZ_CP053102:c2791573-2791351 [Bacillus subtilis subsp. subtilis str. 168]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin