Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2650016..2650341 Replicon chromosome
Accession NZ_AP024628
Organism Bacillus subtilis strain BEST3145

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6K00_RS13830 Protein ID WP_004398662.1
Coordinates 2650016..2650195 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2650119..2650341 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K00_RS13820 (2649242) 2649242..2649379 - 138 WP_003229934.1 hypothetical protein -
K6K00_RS13825 (2649421) 2649421..2649870 - 450 WP_003229933.1 phage portal protein -
K6K00_RS13830 (2650016) 2650016..2650195 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2650119) 2650119..2650341 - 223 NuclAT_0 - Antitoxin
- (2650119) 2650119..2650341 - 223 NuclAT_0 - Antitoxin
- (2650119) 2650119..2650341 - 223 NuclAT_0 - Antitoxin
- (2650119) 2650119..2650341 - 223 NuclAT_0 - Antitoxin
K6K00_RS13835 (2650575) 2650575..2650664 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6K00_RS13840 (2650918) 2650918..2651361 - 444 WP_003229930.1 phage tail tube protein -
K6K00_RS13845 (2651364) 2651364..2652764 - 1401 WP_003229929.1 phage tail sheath family protein -
K6K00_RS13850 (2652765) 2652765..2652956 - 192 WP_010886574.1 hypothetical protein -
K6K00_RS13855 (2652953) 2652953..2653390 - 438 WP_003229927.1 hypothetical protein -
K6K00_RS13860 (2653403) 2653403..2653906 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6K00_RS13865 (2653903) 2653903..2654265 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6K00_RS13870 (2654262) 2654262..2654657 - 396 WP_004398566.1 DUF3199 family protein -
K6K00_RS13875 (2654661) 2654661..2654972 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2619529..2674880 55351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39141 WP_004398662.1 NZ_AP024628:2650016-2650195 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39141 NZ_AP024628:2650016-2650195 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39141 NZ_AP024628:c2650341-2650119 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References