142648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2677825..2678150 Replicon chromosome
Accession NZ_CP045812
Organism Bacillus subtilis strain P8_B3

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag GII89_RS14050 Protein ID WP_004398662.1
Coordinates 2677825..2678004 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2677928..2678150 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GII89_RS14040 2677051..2677188 - 138 WP_003229934.1 hypothetical protein -
GII89_RS14045 2677230..2677679 - 450 WP_003229933.1 phage portal protein -
GII89_RS14050 2677825..2678004 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2677928..2678150 - 223 NuclAT_0 - Antitoxin
- 2677928..2678150 - 223 NuclAT_0 - Antitoxin
- 2677928..2678150 - 223 NuclAT_0 - Antitoxin
- 2677928..2678150 - 223 NuclAT_0 - Antitoxin
GII89_RS14055 2678384..2678473 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
GII89_RS14060 2678727..2679170 - 444 WP_003229930.1 phage tail tube protein -
GII89_RS14065 2679173..2680573 - 1401 WP_003229929.1 phage tail sheath family protein -
GII89_RS14070 2680574..2680765 - 192 WP_010886574.1 hypothetical protein -
GII89_RS14075 2680762..2681199 - 438 WP_003229927.1 hypothetical protein -
GII89_RS14080 2681212..2681715 - 504 WP_003246050.1 HK97 gp10 family phage protein -
GII89_RS14085 2681712..2682074 - 363 WP_003229925.1 YqbH/XkdH family protein -
GII89_RS14090 2682071..2682466 - 396 WP_004398566.1 DUF3199 family protein -
GII89_RS14095 2682470..2682781 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2645075..2698828 53753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T142648 WP_004398662.1 NZ_CP045812:2677825-2678004 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T142648 NZ_CP060807:c1855546-1855214 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 223 bp

>AT142648 NZ_CP045812:c2678150-2677928 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References