Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2657540..2657865 Replicon chromosome
Accession NZ_AP024621
Organism Bacillus subtilis strain BEST3095

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6J89_RS13940 Protein ID WP_004398662.1
Coordinates 2657540..2657719 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2657643..2657865 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J89_RS13930 (2656766) 2656766..2656903 - 138 WP_003229934.1 hypothetical protein -
K6J89_RS13935 (2656945) 2656945..2657394 - 450 WP_003229933.1 phage portal protein -
K6J89_RS13940 (2657540) 2657540..2657719 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2657643) 2657643..2657865 - 223 NuclAT_0 - Antitoxin
- (2657643) 2657643..2657865 - 223 NuclAT_0 - Antitoxin
- (2657643) 2657643..2657865 - 223 NuclAT_0 - Antitoxin
- (2657643) 2657643..2657865 - 223 NuclAT_0 - Antitoxin
K6J89_RS13945 (2658099) 2658099..2658188 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6J89_RS13950 (2658442) 2658442..2658885 - 444 WP_003229930.1 phage tail tube protein -
K6J89_RS13955 (2658888) 2658888..2660288 - 1401 WP_003229929.1 phage tail sheath family protein -
K6J89_RS13960 (2660289) 2660289..2660480 - 192 WP_010886574.1 hypothetical protein -
K6J89_RS13965 (2660477) 2660477..2660914 - 438 WP_003229927.1 hypothetical protein -
K6J89_RS13970 (2660927) 2660927..2661430 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6J89_RS13975 (2661427) 2661427..2661789 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6J89_RS13980 (2661786) 2661786..2662181 - 396 WP_004398566.1 DUF3199 family protein -
K6J89_RS13985 (2662185) 2662185..2662496 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2616843..2678543 61700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T38980 WP_004398662.1 NZ_AP024621:2657540-2657719 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T38980 NZ_AP024621:2657540-2657719 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT38980 NZ_AP024621:c2657865-2657643 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References