Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-ratA/- |
| Location | 681335..681567 | Replicon | chromosome |
| Accession | NC_004668 | ||
| Organism | Enterococcus faecalis V583 | ||
| T1TAdb ID | TA05741 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q837V5 |
| Locus tag | EF_RS16775 | Protein ID | WP_002366178.1 |
| Coordinates | 681335..681451 (+) | Length | 39 a.a. |
Antitoxin (RNA)
| Gene name | ratA | ||
| Locus tag | - | ||
| Coordinates | 681362..681567 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EF_RS03465 (EF0721) | 676773..679031 | + | 2259 | WP_002363179.1 | DNA helicase PcrA | - |
| EF_RS03470 (EF0722) | 679157..681187 | + | 2031 | WP_002361258.1 | NAD-dependent DNA ligase LigA | - |
| EF_RS16775 (EF0723) | 681335..681451 | + | 117 | WP_002366178.1 | putative holin-like toxin | Toxin |
| - | 681362..681567 | - | 206 | - | - | Antitoxin |
| EF_RS03475 (EF0724) | 681769..682074 | + | 306 | WP_002355569.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| EF_RS03480 (EF0725) | 682074..683543 | + | 1470 | WP_002361259.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| EF_RS03485 (EF0726) | 683543..684973 | + | 1431 | WP_002358703.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| EF_RS03490 (EF0727) | 684992..686080 | + | 1089 | WP_002355572.1 | diacylglycerol kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 39 a.a. Molecular weight: 4108.01 Da Isoelectric Point: 5.9482
>T10206 WP_002366178.1 NC_004668:681335-681451 [Enterococcus faecalis V583]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS
Download Length: 117 bp
>T10206 NC_004668:681335-681451 [Enterococcus faecalis V583]
ATGTTTTTGTCCGTTGAAGCAGCGTTGGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGTTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
ATGTTTTTGTCCGTTGAAGCAGCGTTGGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGTTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
Antitoxin
Download Length: 206 bp
>AT10206 NC_004668:c681567-681362 [Enterococcus faecalis V583]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10202 | Enterococcus faecalis V583 |
51.515 |
100 |
0.515 |
| T10203 | Enterococcus faecalis V583 |
51.515 |
100 |
0.515 |
| T6278 | Enterococcus faecalis V583 |
41.935 |
100 |
0.481 |
| T10205 | Enterococcus faecalis V583 |
44.118 |
89.474 |
0.395 |
| T10049 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9 |
39.394 |
94.286 |
0.371 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]