Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-ratA/- |
| Location | 2962267..2962492 | Replicon | chromosome |
| Accession | NC_004668 | ||
| Organism | Enterococcus faecalis V583 | ||
| T1TAdb ID | TA05737 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | - |
| Locus tag | EF_RS14630 | Protein ID | WP_021164442.1 |
| Coordinates | 2962391..2962492 (-) | Length | 34 a.a. |
Antitoxin (RNA)
| Gene name | ratA | ||
| Locus tag | - | ||
| Coordinates | 2962267..2962454 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EF_RS14600 (EF3082) | 2957485..2958438 | - | 954 | WP_002370087.1 | siderophore ABC transporter substrate-binding protein | - |
| EF_RS14605 (EF3083) | 2958477..2959232 | - | 756 | WP_002354962.1 | ATP-binding cassette domain-containing protein | - |
| EF_RS14610 (EF3084) | 2959229..2960194 | - | 966 | WP_002387376.1 | iron chelate uptake ABC transporter family permease subunit | - |
| EF_RS14615 (EF3085) | 2960191..2961138 | - | 948 | WP_002354960.1 | iron chelate uptake ABC transporter family permease subunit | - |
| EF_RS14620 (EF3086) | 2961323..2961775 | + | 453 | WP_002378959.1 | YueI family protein | - |
| EF_RS14625 (EF3087) | 2961957..2962058 | - | 102 | WP_021164441.1 | putative holin-like toxin | - |
| - | 2962267..2962454 | + | 188 | - | - | Antitoxin |
| EF_RS14630 (EF3088) | 2962391..2962492 | - | 102 | WP_021164442.1 | putative holin-like toxin | Toxin |
| EF_RS14635 (EF3089) | 2962683..2964953 | - | 2271 | WP_002399785.1 | bifunctional glutamate--cysteine ligase/glutathione synthetase | - |
| EF_RS14640 (EF3090) | 2965124..2965624 | + | 501 | WP_002378961.1 | cysteine hydrolase family protein | - |
| EF_RS14645 (EF3091) | 2966185..2967081 | + | 897 | WP_002354953.1 | YitT family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 34 a.a. Molecular weight: 3625.38 Da Isoelectric Point: 4.5869
>T10203 WP_021164442.1 NC_004668:c2962492-2962391 [Enterococcus faecalis V583]
MSIEATLELMISFATLVALLIFGILEATKNDKK
MSIEATLELMISFATLVALLIFGILEATKNDKK
Download Length: 102 bp
>T10203 NC_004668:c2962492-2962391 [Enterococcus faecalis V583]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA
Antitoxin
Download Length: 188 bp
>AT10203 NC_004668:2962267-2962454 [Enterococcus faecalis V583]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10202 | Enterococcus faecalis V583 |
87.879 |
100 |
0.879 |
| T10205 | Enterococcus faecalis V583 |
57.576 |
100 |
0.576 |
| T10206 | Enterococcus faecalis V583 |
51.515 |
100 |
0.515 |
| T6278 | Enterococcus faecalis V583 |
44.444 |
100 |
0.444 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]