SecReT6, T6SS database

Burkholderia

Experimental investigation has been performed.

Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS01276	i4b	Burkholderia cenocepacia strain K56-2	chromosome (NZ_LAUA01000004)	63074..82939	anti-eukaryotic
T6SS00114	i3	Burkholderia thailandensis E264	chromosome II (NC_007650)	2282208..2308569	-
T6SS00115	i4b	Burkholderia thailandensis E264	chromosome I (NC_007651)	3396298..3416317	anti-bacterial; effector translocation; adherence
T6SS00070	i1	Burkholderia mallei ATCC 23344	chromosome II (NC_006349)	735641..772695	anti-eukaryotic; effector translocation; virulence
T6SS00075	i1	Burkholderia pseudomallei K96243	chromosome II (NC_006351)	2036034..2064669	anti-eukaryotic; effector translocation; virulence
T6SS00113	i1	Burkholderia thailandensis E264	chromosome II (NC_007650)	996276..1025886	anti-eukaryotic; virulence
T6SS00292	i4b	Burkholderia cenocepacia J2315	chromosome I (NC_011000)	363015..382880	anti-eukaryotic; effector translocation; virulence
T6SS01006	i4b	Burkholderia pseudomallei K96243	chromosome I (CP009538)	2062195..2082181	-
T6SS01196	i4b	Burkholderia cenocepacia H111	chromosome (NZ_HG938370)	347990..367838	anti-bacterial
T6SS01197	i2	Burkholderia cenocepacia H111	chromosome (NZ_HG938371)	172983..201438	anti-bacterial
T6SS01265	i4b	Burkholderia glumae 336gr-1	chromosome (AYPW01000191)	2..8161	anti-bacterial
T6SS01292	i3	Burkholderia pseudomallei K96243	chromosome II (CP009537)	1455143..1478378	-
T6SS01293	i3	Burkholderia pseudomallei K96243	chromosome II (CP009537)	1914678..1943867	-
T6SS01294	i3	Burkholderia pseudomallei K96243	chromosome II (CP009537)	2018346..2040803	-
T6SS01295	i3	Burkholderia pseudomallei K96243	chromosome II (CP009537)	2499073..2525393	-
T6SS01300	i4b	Burkholderia gladioli strain NGJ1	chromosome (LEKY01000012)	91265..111362	anti-bacterial; anti-eukaryotic; effector translocation
T6SS01301	i3	Burkholderia gladioli strain NGJ1	chromosome (LEKY01000074)	55199..85982	anti-bacterial; anti-eukaryotic; effector translocation
T6SS00343	i4b	Burkholderia glumae BGR1	chromosome I (NC_012724)	397352..417437	anti-bacterial
T6SS00126	i4b	Burkholderia cenocepacia AU 1054	chromosome I (NC_008060)	2880426..2919827	anti-bacterial; anti-eukaryotic
T6SS00932	Unknown	Burkholderia pseudomallei Bp340	chromosome (-)	-	anti-eukaryotic
T6SS17508	i3	Burkholderia glumae BGR1	chromosome II (NC_012721)	154526..188085	-
T6SS17509	i2	Burkholderia glumae BGR1	chromosome II (NC_012721)	1382281..1422638	anti-eukaryotic
T6SS17510	Unknown	Burkholderia glumae BGR1	chromosome II (NC_012721)	878998..900488	anti-eukaryotic

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0126	BMAA1517	T6SS00070	protein	Transcription regulator	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	1646532..1647593 (-)	499517952	Hcp1 (BMAA0742) expression (↓)
REG0127	BMAA0746 (VirG)	T6SS00070	protein	TCS-RR	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	764773..765510 (+)	490311617	Hcp1 (BMAA0742) expression (↓)
REG0128	BMAA0745 (VirA)	T6SS00070	protein	TCS-HK	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	762932..764776 (+)	490305845	Hcp1 (BMAA0742) expression (↓)
REG0129	BMAA0746 (VirG)	T6SS00070	protein	TCS-RR	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	764773..765510 (+)	53717366	BMAA0742 (Hcp1) expression (↓); BMAA0729.1 (TssM1) expression (↓)
REG0130	BMAA0745 (VirA)	T6SS00070	protein	TCS-HK	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	763148..764776 (+)	53717365	BMAA0746 (VirG) (↓)
REG0131	BPSL3431 (TctR)	T6SS00074	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006350)	4073388..4074029 (-)	53721038	T6SS-2 (hcp2) transcript (↑)
REG0132	BPSL2246 (PpiB)	T6SS00076 ; T6SS00077	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006350)	2708622..2709113 (+)	53719855	T6SS-3 (BPSS2099/TssCIII and BPSS2098/HcpIII) expression (↑); T6SS-6 (hcp6) transcript (↓)
REG0133	BPSS1504	T6SS00077	protein	Unknown	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2052905..2055547 (+)	499518990	hcp1 secretion
REG0134	BPSS1546 (BsaN)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2100565..2101230 (-)	490660320	BPSS1495 (virA) promotor (↓)
REG0135	BPS_RS27070 (bicA)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2087441..2087956 (-)	490293043	BPSS 1495(virA) (↓)
REG0136	BPS_RS27175 (bprP)	T6SS00077	protein	BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2105881..2106081 (+)	490293055	BPSS1546 (BsaN) (↓)
REG0137	BPSS1495 (virA)	T6SS00077	protein	TCS-RR; BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2038711..2040555 (-)	499518988	T6SS-1 transpript (↓)
REG0138	BPSS1494 (virG)	T6SS00077	protein	TCS-HK; BsaN regulon	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2037977..2038714 (-)	490663798	BPSS1495 (virA) (↓)
REG0139	BPSL1105 (bprP)	T6SS00077	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei K96243	chromosome (NC_006350)	1275668..1276300 (+)	490290369	tssA expression (↓)
REG0140	bprp	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (HM447214)	175..1146 (+)	298239796	tssA expression (↓)
REG0142	bspR	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (HM358865)	258..890 (+)	298239780	tssA expression (↓)
REG0144	BPSS1520 (bprC)	T6SS00077	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2072125..2073186 (-)	499518995	tssA expression (↓)
REG0145	BPSS1495 (virA)	T6SS00077	protein	TCS-HK	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2038711..2040555 (-)	53722517	hcp1 expression (↓)
REG0146	BPSS1494 (virG)	T6SS00077	protein	TCS-RR	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2037977..2038714 (-)	53722516	hcp1 expression (↓)
REG0153	BTH_I1281 (OxyR)	T6SS00114	protein	Global regulator	Burkholderia thailandensis E264	chromosome (NC_007651)	1432632..1433591 (+)	497575020	BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0154	BTH_I0691 (Zur)	T6SS00114	protein	Global regulator	Burkholderia thailandensis E264	chromosome (NC_007651)	796074..796538 (-)	497578547	BTH_RS09735 (T6SS-4) Promotor,−541 to −1 relative to the ATG start codon (↑)
REG0155	BTH_II1510 (BtaR1)	T6SS00115	protein	QS regulatory pathway	Burkholderia thailandensis E264	chromosome (NC_007650)	1779070..1779789 (-)	497583165	BTH_I2691/BTH_I2693-99/BTH_I2701-702 (↓)
REG0324	WQ49_05050 (cepR)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	545988..546707 (-)	815852483	T6SS promotor (P (BCAL0340) ) (↓)
REG0325	WQ49_20245 (cciR)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	843677..844378 (+)	815850423	Unknown (↑)
REG0326	WQ49_19595 (atsR)	T6SS01276	protein	TCS-RR	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	710895..712715 (+)	815849700	T6SS transcripts (↑); T6SS expression (↑)
REG0327	WQ49_05060 (cepI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	547435..548043 (+)	815852485	T6SS expression (↓)
REG0328	WQ49_20250 (cciI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000016)	844665..845255 (+)	815850424	T6SS expression (↓)
REG0359	bglu_1g09700 (tepR)	T6SS00343	protein	Global regulator	Burkholderia glumae BGR1	chromosome (NC_012724)	1045102..1046502 (-)	-	Unknown (↓)
REG0141	bsaN	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (-)	-	-	tssA expression (↓)
REG0143	bprc	-	protein	bspR-dependent signalling cascade	Burkholderia pseudomallei strain KHW	chromosome (-)	-	-	tssA expression (↓)
REG0372	BMUL_RS00795 (hns)	-	protein	Transcription regulator	Burkholderia multivorans ATCC 17616	chromosome (NC_010084)	179094..179390 (+)	WP_006401402.1	T6SS (↑)

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01464	BTH_II1883 (TseM)	Tie	-	T6SS00114	Burkholderia thailandensis E264	chromosome (NC_007650)	2281342..2281767 (-)	83718045
EFF01825	BTH_II1884 (TseZ)	Tie	-	T6SS00114	Burkholderia thailandensis E264	chromosome (NC_007650)	2281790..2282149 (-)	497579572
EFF01517	BCAM1857 (TecA)	DddA	-	-	Burkholderia cenocepacia J2315	chromosome (NC_011001)	2076087..2076566 (+)	206563705
EFF00140	BTH_I0068 (Tae2)	Tae	IMU00071	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	73967..74407 (+)	83720828
EFF01894	ACI79_RS12840 (TseTBg1)	Tde	IMU00383	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000011)	27037..27744 (-)	836689521
EFF01895	AC179_RS29610 (Hcp-2)	Tde	IMU00385	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000082)	22675..23391 (-)	836692495
EFF01900	ACI79_RS22680 (TseTBg3)	Tde	IMU00384	T6SS01301	Pseudomonas aeruginosa PAO1	chromosome (LEKY01000067)	197941..198465 (-)	836690956
EFF01897	ACI79_RS29395 (23tge)	Tge	-	T6SS01300	Burkholderia gladioli NGJ1	chromosome (LEKY01000073)	105319..106497 (+)	920807605
EFF00145	BTH_I2698 (Tle1)	Tle	IMU00076	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3089237..3091639 (-)	83721061
EFF01898	ACI79_RS26075 (13tle)	Tle	-	T6SS01300	Burkholderia gladioli NGJ1	chromosome (LEKY01000069)	193895..195619 (+)	836691417
EFF01899	ACI79_RS23485 (9tle)	Tle	-	T6SS01300	Burkholderia gladioli NGJ1	chromosome (LEKY01000068)	142254..143846 (+)	836691007
EFF01902	ACI79_RS09760 (12tpe)	Tpe	-	T6SS01300	Burkholderia gladioli NGJ1	chromosome (LEKY01000008)	79857..82490 (+)	836689122
EFF00086	BMA_RS19535	Tse	-	T6SS00070	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	736735..737958 (-)	77358950
EFF00136	BTH_RS00455	Tse	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007650)	100474..102714 (+)	83716109
EFF00137	BTH_RS01610	Tse	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007650)	379615..380514 (-)	83716914
EFF00150	BTH_RS28610	Tse	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3674112..3676352 (+)	83719543
EFF00142	BTH_RS25940	Tse	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3077299..3080322 (-)	83720200
EFF00141	BTH_RS21555	Tse	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	2056900..2057376 (-)	83721528
EFF00087	BMA_RS19580	-	-	T6SS00070	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	750563..753586 (-)	53717363
EFF00088	BMA_RS19605	-	-	T6SS00070	Burkholderia mallei ATCC 23344	chromosome (NC_006349)	759926..760435 (-)	77358963
EFF00094	BPS_RS26895	-	-	T6SS00075	Burkholderia pseudomallei K96243	chromosome (NC_006351)	2043052..2043561 (+)	53722520
EFF00092	BPS_RS25320	-	-	T6SS00075	Burkholderia pseudomallei K96243	chromosome (NC_006351)	1633710..1635950 (-)	53722235
EFF00138	BTH_RS04480	-	-	T6SS00113	Burkholderia thailandensis E264	chromosome (NC_007650)	1009425..1012463 (-)	83717090
EFF01271	BTH_RS04505	-	-	T6SS00113	Burkholderia thailandensis E264	chromosome (NC_007650)	1018597..1019085 (-)	83716550
EFF00135	BTH_RS00450	-	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007650)	97680..100460 (+)	83716745
EFF00149	BTH_RS28605	-	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3671318..3674098 (+)	83718625
EFF00147	BTH_RS26010	-	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3097448..3100246 (-)	83718826
EFF00144	BTH_RS25975	-	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3085793..3089128 (-)	83720129
EFF00143	BTH_RS25950	-	-	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3081345..3084173 (-)	83718482
EFF00353	QU43_RS38250	-	-	T6SS00292	Burkholderia cenocepacia J2315	chromosome (NC_011000)	368997..369500 (+)	206558749
EFF01848	I35_RS01730 (hcp)	-	-	T6SS01196	Burkholderia cenocepacia H111	chromosome (NZ_HG938370)	353973..354476 (+)	493523014
EFF01849	WQ49_11820 (hcp)	-	-	T6SS01276	Burkholderia cenocepacia strain K56-2 scf7180000000051	chromosome (NZ_LAUA01000004)	76454..76957 (-)	493523014
EFF01896	AC179_RS29610 (Hcp-2)	-	-	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000074)	57344..57847 (+)	738096046
EFF01901	AC179_RS13930 (Hcp-1)	-	-	T6SS01300	Burkholderia gladioli NGJ1	chromosome (LEKY01000012)	95172..95690 (+)	503461802
EFF00429	BGLU_RS23285	-	-	T6SS17509	Burkholderia glumae BGR1	chromosome (NC_012721)	1418865..1419350 (+)	WP_012733890.1
EFF00430	BGLU_RS01955	-	-	T6SS00343	Burkholderia glumae BGR1	chromosome (NC_012724)	403385..403888 (+)	WP_012734481.1
EFF76636	BCEN_RS18170 (tecA)	-	-	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008061)	779302..779781 (+)	WP_011547418.1
EFF76637	BCEN_RS13090 (tle1)	Tle	IMU38210	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	2888616..2890877 (-)	WP_011546572.1
EFF76638	BCEN_RS13180 (tne1)	Tde	IMU38211	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	2911927..2916584 (-)	WP_011694122.1
EFF76639	BCEN_RS16675 (tne2)	Tde	IMU38212	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008061)	433352..437836 (+)	WP_011547150.1
EFF76640	BCEN_RS22905 (tpe1)	Tme	IMU38213	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008061)	1873432..1876008 (-)	WP_011548259.1
EFF76641	BCEN_RS06980 (tle2)	Tle	IMU38214	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	1552877..1554958 (-)	WP_011545611.1
EFF76652	BGLU_RS18660	-	-	T6SS17508	Burkholderia glumae BGR1	chromosome (NC_012721)	159409..159891 (+)	WP_012733029.1
EFF76653	BGLU_RS23285	-	-	T6SS17510	Burkholderia glumae BGR1	chromosome (NC_012721)	897718..898275 (-)	WP_012733560.1

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector
IMU00071	BTH_I0069 (Tai2)	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	74394..74789 (+)	83719910	EFF00140
IMU00076	BTH_I2699 (Tli1)	T6SS00115	Burkholderia thailandensis E264	chromosome (NC_007651)	3091636..3092235 (-)	83720426	EFF00145
IMU00383	ACI79_RS12840 (TsiTBg1)	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000011)	27037..27744 (-)	836689521	EFF01894
IMU00384	ACI79_RS22675 (TsiTBg3)	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000067)	197212..197877 (-)	920807205	EFF01900
IMU00385	ACI79_RS32200 (TsiTBg2)	T6SS01301	Burkholderia gladioli NGJ1	chromosome (LEKY01000082)	23400..23981 (-)	920807827	EFF01895
IMU38210	BCEN_RS13095 (tli1)	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	2890864..2891784 (-)	WP_175810064.1	EFF76637
IMU38211	BCEN_RS33190 (tni1)	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	2911341..2911916 (-)	WP_011546584.1	EFF76638
IMU38212	BCEN_RS33450 (tni2)	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008061)	437845..438333 (+)	WP_011547151.1	EFF76639
IMU38213	BCEN_RS33835 (tpi1)	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008061)	1872451..1872882 (-)	WP_077190848.1	EFF76640
IMU38214	BCEN_RS06975 (tli2)	T6SS00126	Burkholderia cenocepacia AU 1054	chromosome (NC_008060)	1551205..1552767 (-)	WP_011545610.1	EFF76641

Experimental investigation has been performed.

Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector
ACP00021	BTH_II2139 (hmuR)	T6SS00114	chaperone	Burkholderia thailandensis E264	chromosome (NC_007650)	2626542..2628827 (+)	644827063	-	BTH_II1884 (TseZ)
ACP00022	BTH_RS20365 (mnoT)	T6SS00114	chaperone	Burkholderia thailandensis E264	chromosome (NC_007651)	1796067..1798403 (+)	497575584	-	BTH_II1883 (TseM)
ACP44070	BGLU_RS21515	T6SS17510	adaptor	Burkholderia glumae BGR1	chromosome (NC_012721)	888978..891614 (-)	WP_012733555.1	-	-