Vibrio cholerae


experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0020 experimental Qrr4 T6SS01061 experimental ncRNA Unknown Vibrio cholerae 2740-80 chromosome (NZ_CP016325) - - VCA0107 mRNA (↑)
REG0021 experimental GPY04_RS11195 (CytR) T6SS01168 experimental protein Unknown Vibrio cholerae C6706 chromosome (NZ_CP046844) 2449479..2450486 (-) 446146597 Unknown (↓)
REG0022 experimental GPY04_RS03590 (TfoX) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 777344..777952 (+) 487807468 Unknown (↓)
REG0023 experimental GPY04_RS00870 (HapR) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 164935..165546 (-) 446262243 Unknown (↓)
REG0024 experimental GPY04_RS13335/VC0070 (tsrA) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2888303..2888587 (+) 445982516 T6SS transcripts (↑)
REG0025 experimental Qrr1 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0026 experimental Qrr2 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0027 experimental Qrr3 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0028 experimental Qrr4 quorum regulatory RNA T6SS01168 experimental ncRNA QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) - - VCA0107 mRNA (↑)
REG0029 experimental GPY04_RS15835 (luxO) T6SS01168 experimental protein QS regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046845) 273631..274983 (-) 446367907 VC0070 (tsrA) (↑); GPY04_RS00870 (hapR) (↑)
REG0030 experimental GPY04_RS13825 (QstR) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2994333..2994977 (-) 447111060 Unknown (↓)
REG0033 experimental GPY04_RS01040 (ChiS) T6SS01168 experimental protein ChiS-induced regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 210606..213995 (-) 446410424 Necessory for TfoX/TfoR (↓)
REG0034 experimental GPY04_RS03200 (chiA2) T6SS01168 experimental protein ChiS-induced regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 692014..695280 (+) 487807405 GPY04_RS01040 (ChiS) (↓)
REG0035 experimental GPY04_RS07700 (chiA1) T6SS01168 experimental protein ChiS-induced regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 1709613..1712153 (-) 446755770 GPY04_RS01040 (ChiS) (↓)
REG0036 experimental VC1920/VCA1552_01695 (LonA) T6SS01112 experimental protein Unknown Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1845472..1847832 (-) 446970355 Unknown (↑)
REG0039 experimental VC_RS13930 (VasH) T6SS00002 experimental protein Global regulator Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 128790..130382 (+) 446006938 VCA0017 (hcp-2) transcript (↓)
REG0180 experimental VC0395_RS17530 (TsrA) T6SS00208 insolico; T6SS00487 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2598392..2598676 (-) 445982516 T6SS Transciption (↑)
REG0181 experimental VC0395_0020/VCA0117 (bEBP/vasH) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009456) 22315..23907 (-) 446006938 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓)
REG0182 experimental VC0395_A2109 (rpoN) T6SS00208 insolico protein Global regulator Vibrio cholerae O395 chromosome (NC_009457) 2265078..2266541 (+) 446727517 T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓)
REG0288 experimental VCA0566 (VxrB) T6SS00002 experimental protein TCS-RR Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 504728..505384 (+) 446737785 Unknown (↑)
REG0289 experimental VCA0933 (CspV) T6SS00002 experimental protein c-di-GMP regulatory pathway Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 886068..886280 (+) 446027150 Unknown (↓)
REG0290 experimental VCA1552_01380 (VdcA/ycdT) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1482426..1483715 (+) 446892247 the levels of c-di-GMP (↑)
REG0291 experimental VCA1552_02536 (CdpA/YfgF) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2739669..2742158 (-) 446417730 the levels of c-di-GMP (↓)
REG0292 experimental VCA1552_02898 (VasH) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 128889..130481 (+) 446006938 VCA1552_00900 (TfoX) (↓)
REG0293 experimental VCA1552_00351 (HapR) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 340447..341058 (-) 446262243 Unknown; Hcp expression and secretion
REG0294 experimental VCA1552_RS04890 (ihfA) T6SS01112 experimental protein Transcription regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1028170..1028466 (+) 447152004 Hcp secretion (↓)
REG0295 experimental VCA1552_RS08565 (ihfB) T6SS01112 experimental protein Transcription regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1839353..1839631 (-) 446089486 Hcp secretion (↓)
REG0296 experimental VCA1552_RS03895 (LuxO) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 818142..819509 (+) 487814784 Hcp expression and secretion (↑)
REG0297 experimental VCA1552_RS17020 (cqsa) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 455238..456407 (-) 446962656 Hcp expression and secretion (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0299 experimental VCA1552_RS00505 (hfq) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 92673..92936 (+) 446974616 VCA1552_00351 (HapR) (↑)
REG0300 experimental VCA1552_RS11610 (RpoN) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2488023..2489486 (+) 446727517 Hcp expression and secretion (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0304 experimental VCA1552_00900 (TfoX) T6SS01112 experimental protein Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 952868..953476 (+) 487807468 VC0396/VCA1552_00154 (QstR) (↓)
REG0306 experimental VCA1552_01510 (TfoY) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1636980..1637567 (+) 446282733 Unknown (↓)
REG0307 experimental VCA1552_RS06160 (lonA) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1315238..1316887 (+) 446116573 VCA1552_01510 (TfoY) (↑)
REG0308 experimental VCA1552_RS10420 (cdgL) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2215844..2217361 (-) 446975354 the levels of c-di-GMP (↓)
REG0309 experimental VCA1552_RS04310 (cdgK) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 901594..903063 (+) 487807420 the levels of c-di-GMP (↓)
REG0310 experimental VCA1552_RS04130 (cdgH) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 861187..863208 (+) 446848493 the levels of c-di-GMP (↓)
REG0311 experimental VCA1552_RS02130 (rocS) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 425233..427287 (-) 447034155 the levels of c-di-GMP (↑)
REG0312 experimental VCA1552_RS12850 (cdgJ) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2733319..2734545 (-) 446210986 the levels of c-di-GMP (↑)
REG0313 experimental VCA1552_RS17835 (cdgD) T6SS01112 experimental protein c-di-GMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024868) 633312..635195 (+) 446210820 the levels of c-di-GMP (↓)
REG0314 experimental TfoY T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (-) - - Unknown (↓)
REG0315 experimental VCV52_RS10780 (TfoX) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410501) 68827..69435 (-) 487807468 Unknown (↓)
REG0316 experimental VCV52_RS01020 (VasH) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410497) 212259..213851 (-) 446006947 Unknown (↓)
REG0317 experimental VCV52_RS13040 (rpoN) T6SS00790 experimental protein Global regulator Vibrio cholerae V52 chromosome (NZ_KQ410502) 216932..218395 (-) 446727517 Unknown (↓)
REG0320 experimental VC_A0122 T6SS00002 experimental protein Transcription regulator Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 137379..137621 (+) 9657509 hcp-2 expression (↓)
REG0369 experimental VCV52_RS14135 (wigR/phoB/vxrB) T6SS00790 experimental protein TCS-RR Vibrio cholerae V52 chromosome (NZ_KQ410503) 201806..202495 (-) 446013262 T6SS transcription level (↓)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Effector ID Locus tag (Gene) Classification Cognate immunity protein Related T6SS Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF01442 experimental VCA0285 Tae IMU00291 experimental T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 305200..305871 (+) 15601051
EFF00005 experimental VCA0123 Tge IMU00172 experimental T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 137581..140634 (+) 15600894
EFF00008 experimental VC1418 (TseL, Tle2) Tle IMU00156 experimental T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002505) 1514611..1516536 (+) 15641429
EFF01818 experimental GPY04_RS04830 (TleV1) Tle IMU00356 experimental T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046844) 1067605..1069530 (+) 446298981
EFF00003 experimental VCA0020 (VasX) Tme IMU00166 experimental T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 23395..26652 (+) 15600791
EFF01820 experimental GPY04_RS16385 (VasX) Tme IMU00357 experimental T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046845) 405867..409124 (-) 445992499
EFF00001 experimental VCA0017 - - T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 19781..20299 (+) 15600788
EFF00002 experimental VCA0018 - - T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 20427..22511 (+) 15600789
EFF00004 experimental VCA0118 - - T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 130352..131035 (+) 15600889
EFF00007 experimental VC_RS06850 - - T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002505) 1510278..1513769 (+) 15641427
EFF00006 experimental VC_RS06845 - - T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002505) 1509632..1510150 (+) 15641426
EFF01819 experimental GPY04_RS04820 (VgrG-1) - - T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046844) 1063272..1066763 (+) 446134261
EFF01821 experimental GPY04_RS15920 - IMU00358 experimental T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046845) 291886..294939 (-) 446035440
EFF01850 experimental VCA1552_RS05805 (hcp) - - T6SS01112 experimental Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 1238150..1238668 (+) 447065691
EFF01010 experimental VCV52_RS01015 - - T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 211606..212262 (-) WP_001223375.1
EFF01011 experimental VCV52_RS00990 (vgrG3) - IMU00272 experimental T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 202021..205074 (-) WP_000113305.1
EFF76626 experimental VCV52_RS00220 Tae IMU38206 experimental T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 32099..32770 (-) WP_000132861.1
EFF76627 experimental VCV52_RS01470 (vasX) Tme IMU38207 experimental T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 316035..319292 (-) WP_000070352.1
EFF76628 experimental VCV52_RS01485 (hcp2) - - T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 322388..322906 (-) WP_001142930.1
EFF76629 experimental VCV52_RS01480 - - T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 320176..322260 (-) WP_000212092.1
EFF76630 experimental VCV52_RS06825 (tseL) Tle IMU38208 experimental T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410498) 432292..434217 (-) WP_000376836.1
EFF76631 experimental VCV52_RS06835 (vgrG1) - - T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410498) 435059..438550 (-) WP_000212116.1
EFF76632 experimental VCV52_RS06840 (hcp2) - - T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410498) 438678..439196 (-) WP_001142947.1

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Immunity protein ID Locus tag (Gene) Related T6SS Organism                 Replicon (Accession) Coordinates (Strand) Protein GI Cognate effector
IMU00156 experimental VC1419 (TsiV1) T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002505) 1516533..1517276 (+) 15641430 EFF00008 experimental
IMU00166 experimental VCA0021 (TsiV2) T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 26653..27381 (+) 15600792 EFF00003 experimental
IMU00172 experimental VCA0124 (TsiV3) T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 140631..140999 (+) 15600895 EFF00005 experimental
IMU00291 experimental VC_RS14695 T6SS00002 experimental Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002506) 305996..306223 (+) 15601052 EFF01442 experimental
IMU00356 experimental GPY04_RS04835 (TsiV1) T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046844) 1069527..1070270 (+) 446694188 EFF01818 experimental
IMU00357 experimental GPY04_RS16380 (TsiV2) T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046845) 405138..405866 (-) 446826823 EFF01820 experimental
IMU00358 experimental GPY04_RS15915 (TsiV3) T6SS01168 experimental Vibrio cholerae C6706 chromosome (NZ_CP046845) 291521..291889 (-) 446984039 EFF01821 experimental
IMU00272 experimental VCV52_RS00985 T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 201656..202024 (-) WP_001061295.1 EFF01011 experimental
IMU38206 experimental VCV52_RS20260 T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 31747..31974 (-) WP_001911595.1 EFF76626 experimental
IMU38207 experimental VCV52_RS01465 T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410497) 315306..316034 (-) WP_000904079.1 EFF76627 experimental
IMU38208 experimental VCV52_RS06820 T6SS00790 experimental Vibrio cholerae V52 chromosome (NZ_KQ410498) 431552..432295 (-) WP_000771534.1 EFF76630 experimental

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
ID           Locus tag (Gene) Organism                 Replicon (Accession) Coordinates (Strand) Protein GI Response to T6SS attack Known or putative function
RSF000033 experimental VCV52_0688 (wigR/phoB/vxrB) Vibrio cholerae V52 chromosome (NZ_KQ410503) 201806..202495 (-) 446013262 protective cell-wall damage response
RSF000034 experimental VCV52_RS11930 (vpsA) Vibrio cholerae V52 chromosome (NZ_KQ410501) 316448..317566 (-) 446679410 protective Vibrio polysaccharide (VPS) expression

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Accessory protein ID Locus tag (Gene) Related T6SS Type             Organism                 Replicon (Accession) Coordinates (Strand) Protein GI Related structure protein Related effector
ACP00001 experimental VC1417 T6SS00002 experimental adaptor Vibrio cholerae O1 biovar El Tor str. N16961 chromosome (NC_002505) 1513748..1514608 (+) 15641428 VgrG-1 VC1418 (TseL)
ACP00025 experimental VCV52_1391 (tap-1) T6SS00790 experimental adaptor Vibrio cholerae V52 chromosome (NZ_KQ410498) 434220..435080 (-) 446336115 VgrG-1 TseL
ACP00026 experimental VCV52_RS01475 (vasW) T6SS00790 experimental adaptor Vibrio cholerae V52 chromosome (NZ_KQ410497) 319289..320176 (-) 447180717 - VasX
ACP00041 experimental A55_1501 (tap-2) - adaptor Vibrio cholerae 1587 chromosome (NZ_KQ410627) 235783..236571 (+) 446538621 VgrG-1 TseL
ACP44067 experimental VCV52_RS01000 (tagA) T6SS00790 experimental structure affiliated protein Vibrio cholerae V52 chromosome (NZ_KQ410497) 205313..206575 (-) WP_000073086.1 VCV52_RS01060 (tssE); VCV52_RS01055 (tssF); VCV52_RS01030 (tssL); VCV52_RS01005 (tssM) VCV52_RS06835 (vgrG1); VCV52_RS00990 (vgrG3); VCV52_RS01485 (hcp-2)