297241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/-
Location 3926108..3926694 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NCTC12023_04149 Protein ID SUH99400.1
Coordinates 3926326..3926694 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NCTC12023_04148 Protein ID SUH99399.1
Coordinates 3926108..3926329 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC12023_04143 3921128..3922237 + 1110 SUH99394.1 leucine-specific binding protein -
NCTC12023_04144 3922297..3923223 + 927 SUH99395.1 high-affinity branched-chain amino acid transporter permease -
NCTC12023_04145 3923220..3924497 + 1278 SUH99396.1 high-affinity branched-chain amino acid transporter permease -
NCTC12023_04146 3924494..3925261 + 768 SUH99397.1 high-affinity branched-chain amino acid transport ATP-binding protein -
NCTC12023_04147 3925263..3925976 + 714 SUH99398.1 high-affinity branched-chain amino acid transport ATP-binding protein -
NCTC12023_04148 3926108..3926329 + 222 SUH99399.1 antitoxin Antitoxin
NCTC12023_04149 3926326..3926694 + 369 SUH99400.1 death on curing protein Toxin
NCTC12023_04150 3926953..3928269 + 1317 SUH99401.1 glycerol-3-phosphate-binding periplasmic protein -
NCTC12023_04151 3928333..3929220 + 888 SUH99402.1 glycerol-3-phosphate transporter permease -
NCTC12023_04152 3929217..3930062 + 846 SUH99403.1 sn-Glycerol-3-phosphate transporter permease -
NCTC12023_04153 3930064..3931134 + 1071 SUH99404.1 sn-Glycerol-3-phosphate transport ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3923220..3931871 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T297241 SUH99400.1 UFRD01000002:3926326-3926694 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T297241 UFRD01000002:3926326-3926694 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT297241 SUH99399.1 UFRD01000002:3926108-3926329 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT297241 UFRD01000002:3926108-3926329 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References