Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3194283..3194869 Replicon chromosome
Accession NZ_CP091300
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)


Gene name doc Uniprot ID A0A0R9MYB2
Locus tag L1971_RS16175 Protein ID WP_000174966.1
Coordinates 3194501..3194869 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8F2ZY79
Locus tag L1971_RS16170 Protein ID WP_001599562.1
Coordinates 3194283..3194504 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1971_RS16145 (3189304) 3189304..3190413 + 1110 WP_000822968.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
L1971_RS16150 (3190473) 3190473..3191399 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
L1971_RS16155 (3191396) 3191396..3192673 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
L1971_RS16160 (3192670) 3192670..3193437 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
L1971_RS16165 (3193439) 3193439..3194152 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
L1971_RS16170 (3194283) 3194283..3194504 + 222 WP_001599562.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1971_RS16175 (3194501) 3194501..3194869 + 369 WP_000174966.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L1971_RS16180 (3195128) 3195128..3196444 + 1317 WP_000624749.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
L1971_RS16185 (3196549) 3196549..3197436 + 888 WP_000094074.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
L1971_RS16190 (3197433) 3197433..3198278 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
L1971_RS16195 (3198280) 3198280..3199350 + 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3191396..3200087 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13629.91 Da        Isoelectric Point: 6.4657

>T233094 WP_000174966.1 NZ_CP091300:3194501-3194869 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T233094 NZ_CP128528:c2147077-2146808 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.20 Da        Isoelectric Point: 6.4643

>AT233094 WP_001599562.1 NZ_CP091300:3194283-3194504 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Download         Length: 222 bp

>AT233094 NZ_CP128528:c2147330-2147064 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9MYB2

Antitoxin

Source ID Structure

References