Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/-
Location 3741634..3742220 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag STM14_RS18845 Protein ID WP_001521773.1
Coordinates 3741634..3742002 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag STM14_RS18850 Protein ID WP_001520924.1
Coordinates 3741999..3742220 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS18825 (STM14_4280) 3737194..3738264 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
STM14_RS18830 (STM14_4281) 3738266..3739111 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
STM14_RS18835 (STM14_4282) 3739108..3739995 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
STM14_RS18840 (STM14_4283) 3740059..3741375 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
STM14_RS18845 (STM14_4284) 3741634..3742002 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
STM14_RS18850 (STM14_4285) 3741999..3742220 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
STM14_RS18855 (STM14_4286) 3742352..3743065 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
STM14_RS18860 (STM14_4287) 3743067..3743834 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
STM14_RS18865 (STM14_4288) 3743831..3745108 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
STM14_RS18870 (STM14_4289) 3745105..3746031 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
STM14_RS18875 (STM14_4290) 3746091..3747200 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3736457..3745108 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T26059 WP_001521773.1 NC_016856:c3742002-3741634 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T26059 NC_016856:c3742002-3741634 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT26059 WP_001520924.1 NC_016856:c3742220-3741999 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT26059 NC_016856:c3742220-3741999 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References