207479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 311717..312303 Replicon chromosome
Accession NZ_CP077691
Organism Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)


Gene name doc Uniprot ID A0A0R9MYB2
Locus tag DAX98_RS01420 Protein ID WP_000174966.1
Coordinates 311935..312303 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0R9PI96
Locus tag DAX98_RS01415 Protein ID WP_001535398.1
Coordinates 311717..311938 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX98_RS01390 (306737) 306737..307846 + 1110 WP_108450317.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
DAX98_RS01395 (307906) 307906..308832 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
DAX98_RS01400 (308829) 308829..310106 + 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
DAX98_RS01405 (310103) 310103..310870 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
DAX98_RS01410 (310872) 310872..311585 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
DAX98_RS01415 (311717) 311717..311938 + 222 WP_001535398.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DAX98_RS01420 (311935) 311935..312303 + 369 WP_000174966.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DAX98_RS01425 (312562) 312562..313878 + 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
DAX98_RS01430 (313983) 313983..314870 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
DAX98_RS01435 (314867) 314867..315712 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
DAX98_RS01440 (315714) 315714..316784 + 1071 WP_000907842.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 308829..317521 8692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13629.91 Da        Isoelectric Point: 6.4657

>T207479 WP_000174966.1 NZ_CP077691:311935-312303 [Salmonella enterica subsp. enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T207479 NZ_CP103300:c1028873-1028229 [Endozoicomonas euniceicola]
ATGTTTTACAAAAATCTCAACCCTCAAAAAGCCCTGATCTGGAGAATTACTCACCGGAATAACCTTCCGTGGCTGCTGGA
TAATGGCTTGCACTGCGGAACCAGTACGGTTCGCTCATCTGATTGGGTGGATATAGGGAATCCTGAGCTGATTGATAAAC
GTGGTAATCATCCTGTTCCAGATAAACCTGGTGGAGTATTGAATGATTACGTTCCCTTCTACTTCACCCCTTTTTCGGTG
ATGATGCAGAATATCCACACAGGATGGAGCGTACCCAAAAGGGATAATGACGAAATCGTTATTCTTGTTTCCAGCTTGTA
TCGAATACGAGAGTTGGAACTTCCATTCCTGTTTACGGATAGCCATGCTTATTATATGTGGGCAAACTTTTACAGTGGCC
TCGCTGATCTTGATAAAGTGGACTGGTCAATCCTGCAACGTCGTGATTTTAAGCGGGATCAGGATGATCCAGCCAAGTTT
GAGCGCTATCAGGCAGAGGCTTTGGTTTACCGGCACGTACCAGTAGAAGCATTGCTGGGTGTCGTTTGTTATACCGAAGA
GCTAAAATTGCAGATAGATCAGCTTATGCAGCAGCGAGGGCTTGGGTTGTCAGTCTACGTGCGAACGGGGTGGTATTTCC
AATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8165.23 Da        Isoelectric Point: 6.4643

>AT207479 WP_001535398.1 NZ_CP077691:311717-311938 [Salmonella enterica subsp. enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Download         Length: 222 bp

>AT207479 NZ_CP103300:c1028232-1027159 [Endozoicomonas euniceicola]
ATGATCAAATACACGACAGGCAATCTTCTTGACGCACCTGCCGAAGCTCTGGTTAACACGGTTAACACCGTCGGGGTTAT
GGGAAAAGGTATTGCCCTGATGTTCAAAGAGCGCTTTGACAAAAACATGAAGGAGTACGTCAAAGCCTGCAAGGCTAAAG
AAGTTCAGGTTGGCAAAATGTTTGTCACTAAAACTGATGAGCTTATAGGCCCCCACTGGGTGGTGAATTTTCCGACTAAG
AAGCATTGGCGTTATCCCTCAAAAATGGAGTGGGTGGTTGATGGTTTGCAAGACCTAAAACGCTTTATTCTTGAAGAAAA
TGTCAGGTCCATCGCCATTCCTCCCCTTGGAGCTGGCAATGGCGGTCTTCCCTGGCCTGCCGTTCGTGAGCAGATTGAAC
TGGCTCTGTCAGATTTGCACGATGTAGAGATTCTTATTTTTGAGCCGACTGCAAAATACCAGAATATTGCCAAGTCAAAA
GGTGCTGAAAAGCTGACCCCTGCAAGGGCGTTAATTGCCGAGTTAATCCGTCGCTATTGGGTTCCTGGTATGGAATGCAG
CCTGCTGGAAGTGCAAAAGTTAGCCTGGGTTCTTGAAAGAGTGATTGAGAAACAACAGCTTGAAAACCCTCTCCAGCTTC
AGTTCAGCCCGGAAAATTATGGCCCTTATGCTAACCGCCTGCAGCACGTTTTGAATCATCTGGATGGTAGCTATTTAAAA
AGTGACAAGCGTATAGCGGATAGTAGTCCGCTGGATGTTATTCGCTTTAACGAAAAATATAAAATCAAATTGCAAACTTA
TCTTGAGTCAAAGGCTACAAAATACTTGCCAGCACTTGAGGAAGCCTCGAAGATCATTTCTGGTTTTGAATCTCCTTTCG
GACTAGAGCTGTTGACAACCGTTGACTGGCTGATCAGCAGGGAGAGCTGCAATGGAACGGTTGATGATGTCATGGAAGCA
ATAAAACAATGGCCTGCAGGTTCTAAGTGGGCTTCCAGAAAAGAGAAGTTGTTCAGTGAGCGTGATGTTTCGATAGCTTT
ATCAAGACTTCAGGAAATGAAGATGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9MYB2

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PI96

References