25959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/-
Location 3749258..3749844 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag SL1344_RS18340 Protein ID WP_001521773.1
Coordinates 3749258..3749626 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag SL1344_RS18345 Protein ID WP_001520924.1
Coordinates 3749623..3749844 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS18320 (SL1344_3520) 3744818..3745888 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
SL1344_RS18325 (SL1344_3521) 3745890..3746735 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
SL1344_RS18330 (SL1344_3522) 3746732..3747619 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
SL1344_RS18335 (SL1344_3523) 3747683..3748999 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
SL1344_RS18340 (SL1344_3524) 3749258..3749626 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SL1344_RS18345 (SL1344_3525) 3749623..3749844 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SL1344_RS18350 (SL1344_3526) 3749976..3750689 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
SL1344_RS18355 (SL1344_3527) 3750691..3751458 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
SL1344_RS18360 (SL1344_3528) 3751455..3752732 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
SL1344_RS18365 (SL1344_3529) 3752729..3753655 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
SL1344_RS18370 (SL1344_3530) 3753715..3754824 - 1110 WP_000822973.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3744081..3752732 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T25959 WP_001521773.1 NC_016810:c3749626-3749258 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T25959 NC_016810:c3749626-3749258 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT25959 WP_001520924.1 NC_016810:c3749844-3749623 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT25959 NC_016810:c3749844-3749623 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References