186257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3666719..3667305 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag JJB81_RS17875 Protein ID WP_001521773.1
Coordinates 3666719..3667087 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag JJB81_RS17880 Protein ID WP_001520924.1
Coordinates 3667084..3667305 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS17855 (3662279) 3662279..3663349 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
JJB81_RS17860 (3663351) 3663351..3664196 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JJB81_RS17865 (3664193) 3664193..3665080 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JJB81_RS17870 (3665144) 3665144..3666460 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JJB81_RS17875 (3666719) 3666719..3667087 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JJB81_RS17880 (3667084) 3667084..3667305 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JJB81_RS17885 (3667437) 3667437..3668150 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JJB81_RS17890 (3668152) 3668152..3668919 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JJB81_RS17895 (3668916) 3668916..3670193 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
JJB81_RS17900 (3670190) 3670190..3671116 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JJB81_RS17905 (3671176) 3671176..3672285 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3661542..3670193 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T186257 WP_001521773.1 NZ_CP067397:c3667087-3666719 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T186257 NZ_CP089309:437167-437523 [Thiocapsa bogorovii]
ATGGCCTGGACGATTGAGTTCGATCCGGCCGCCGAACGCGAGCTTGGCAAGCTCGATCCGCCCATCGCCCGCCGCATTCT
GGCGTTTCTGCATGGGCGTGTCGCGCCGCTCGATGACCCGCGCCATCTCGGAGAAGCCCTCAAGGGGTCGAGATTGGGGG
ATTTATGGAAGTACCGGGTCGGTGATTATCGCCTTATCGTGAGTATCGAGGATGACACGGTGCGCCTCCTCGTGGTCCGC
CTCGGTCACCGCCGGGACGTGTATCGGCGGTCAGTCACGCCACGCGCCTGGCAAATAAATCTTTCCCCTTTTGGCGCAAA
CCCCTGTGATGAGGCAAGCCATGAACACGGCATTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT186257 WP_001520924.1 NZ_CP067397:c3667305-3667084 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT186257 NZ_CP089309:436959-437183 [Thiocapsa bogorovii]
ATGCTGGCCATCCGACTCCCCGCCGACGTGGAGCAGCGGCTCGAAGCCTTGGCACGGGCCACGGGGCGCACCAAGACCTT
CTATGCCCGCGAAGCCATCCTTGAGCATCTGGACGACCTTGAGGACGTGTACTTGGCCGAGCAGCGGCTGATCGACATTC
GCGCGGGCAAGACTCAAACCGTGCCGCTGGATGAATTGATGACGCGCTATGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References