Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2473569..2474155 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag IUJ38_RS12235 Protein ID WP_001521773.1
Coordinates 2473569..2473937 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag IUJ38_RS12240 Protein ID WP_001520924.1
Coordinates 2473934..2474155 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS12215 (2469129) 2469129..2470199 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
IUJ38_RS12220 (2470201) 2470201..2471046 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
IUJ38_RS12225 (2471043) 2471043..2471930 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
IUJ38_RS12230 (2471994) 2471994..2473310 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
IUJ38_RS12235 (2473569) 2473569..2473937 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IUJ38_RS12240 (2473934) 2473934..2474155 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUJ38_RS12245 (2474287) 2474287..2475000 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
IUJ38_RS12250 (2475002) 2475002..2475769 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IUJ38_RS12255 (2475766) 2475766..2477043 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
IUJ38_RS12260 (2477040) 2477040..2477966 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
IUJ38_RS12265 (2478026) 2478026..2479135 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2468392..2479940 11548


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T181075 WP_001521773.1 NZ_CP064385:c2473937-2473569 [Salmonella enterica subsp. enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T181075 NZ_CP085802:3170236-3170493 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT181075 WP_001520924.1 NZ_CP064385:c2474155-2473934 [Salmonella enterica subsp. enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT181075 NZ_CP085802:c3170411-3170079 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References