251050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 329534..330120 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name doc Uniprot ID Q57IR9
Locus tag NL712_RS01510 Protein ID WP_000174963.1
Coordinates 329752..330120 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag NL712_RS01505 Protein ID WP_001522145.1
Coordinates 329534..329755 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS01480 (324555) 324555..325664 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NL712_RS01485 (325724) 325724..326650 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NL712_RS01490 (326647) 326647..327924 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
NL712_RS01495 (327921) 327921..328688 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NL712_RS01500 (328690) 328690..329403 + 714 WP_058805605.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
NL712_RS01505 (329534) 329534..329755 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL712_RS01510 (329752) 329752..330120 + 369 WP_000174963.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NL712_RS01515 (330379) 330379..331695 + 1317 WP_000624749.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
NL712_RS01520 (331800) 331800..332687 + 888 WP_000094074.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
NL712_RS01525 (332684) 332684..333529 + 846 WP_023256946.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
NL712_RS01530 (333532) 333532..334602 + 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 326647..335339 8692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13573.85 Da        Isoelectric Point: 6.7252

>T251050 WP_000174963.1 NZ_CP100693:329752-330120 [Salmonella enterica subsp. enterica serovar London]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT251050 WP_001522145.1 NZ_CP100693:329534-329755 [Salmonella enterica subsp. enterica serovar London]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6KCD5

Antitoxin

Source ID Structure

References