Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 298291..298877 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name doc Uniprot ID Q57IR9
Locus tag MOV21_RS01385 Protein ID WP_000174963.1
Coordinates 298509..298877 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8F2ZY79
Locus tag MOV21_RS01380 Protein ID WP_001599562.1
Coordinates 298291..298512 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS01355 (293311) 293311..294420 + 1110 WP_238727984.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
MOV21_RS01360 (294480) 294480..295406 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MOV21_RS01365 (295403) 295403..296680 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
MOV21_RS01370 (296677) 296677..297444 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MOV21_RS01375 (297446) 297446..298159 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MOV21_RS01380 (298291) 298291..298512 + 222 WP_001599562.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOV21_RS01385 (298509) 298509..298877 + 369 WP_000174963.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MOV21_RS01390 (299135) 299135..300451 + 1317 WP_000624742.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MOV21_RS01395 (300556) 300556..301443 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MOV21_RS01400 (301440) 301440..302285 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MOV21_RS01405 (302288) 302288..303358 + 1071 WP_000907842.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 295403..304095 8692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13573.85 Da        Isoelectric Point: 6.7252

>T238416 WP_000174963.1 NZ_CP093392:298509-298877 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T238416 NZ_LR890334:4067358-4067645 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.20 Da        Isoelectric Point: 6.4643

>AT238416 WP_001599562.1 NZ_CP093392:298291-298512 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Download         Length: 222 bp

>AT238416 NZ_LR890334:4067632-4067934 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6KCD5

Antitoxin

Source ID Structure

References