Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 308306..308892 | Replicon | chromosome |
Accession | NZ_CP110931 | ||
Organism | Salmonella enterica strain XM3104 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q57IR9 |
Locus tag | ORG44_RS01405 | Protein ID | WP_000174963.1 |
Coordinates | 308524..308892 (+) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | M7SDJ3 |
Locus tag | ORG44_RS01400 | Protein ID | WP_001520924.1 |
Coordinates | 308306..308527 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ORG44_RS01375 (303333) | 303333..304436 | + | 1104 | WP_023235350.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
ORG44_RS01380 (304496) | 304496..305422 | + | 927 | WP_000003005.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
ORG44_RS01385 (305419) | 305419..306696 | + | 1278 | WP_001541045.1 | branched chain amino acid ABC transporter permease LivM | - |
ORG44_RS01390 (306693) | 306693..307460 | + | 768 | WP_000082080.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
ORG44_RS01395 (307462) | 307462..308175 | + | 714 | WP_000416114.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
ORG44_RS01400 (308306) | 308306..308527 | + | 222 | WP_001520924.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ORG44_RS01405 (308524) | 308524..308892 | + | 369 | WP_000174963.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
ORG44_RS01410 (309151) | 309151..310467 | + | 1317 | WP_000624747.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
ORG44_RS01415 (310572) | 310572..311459 | + | 888 | WP_038394052.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
ORG44_RS01420 (311456) | 311456..312301 | + | 846 | WP_023235349.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
ORG44_RS01425 (312304) | 312304..313374 | + | 1071 | WP_011264401.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 305419..314111 | 8692 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13573.85 Da Isoelectric Point: 6.7252
>T264493 WP_000174963.1 NZ_CP110931:308524-308892 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
Download Length: 369 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H6KCD5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C6Z871 |