Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4475653..4476239 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag JI996_RS22190 Protein ID WP_001521773.1
Coordinates 4475653..4476021 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag JI996_RS22195 Protein ID WP_001520924.1
Coordinates 4476018..4476239 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS22170 (4471213) 4471213..4472283 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
JI996_RS22175 (4472285) 4472285..4473130 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JI996_RS22180 (4473127) 4473127..4474014 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JI996_RS22185 (4474078) 4474078..4475394 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JI996_RS22190 (4475653) 4475653..4476021 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JI996_RS22195 (4476018) 4476018..4476239 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JI996_RS22200 (4476371) 4476371..4477084 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JI996_RS22205 (4477086) 4477086..4477853 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JI996_RS22210 (4477850) 4477850..4479127 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
JI996_RS22215 (4479124) 4479124..4480050 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JI996_RS22220 (4480110) 4480110..4481219 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4470476..4481219 10743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T186453 WP_001521773.1 NZ_CP068018:c4476021-4475653 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T186453 NZ_CP089445:692985-693272 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT186453 WP_001520924.1 NZ_CP068018:c4476239-4476018 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT186453 NZ_CP089445:693259-693561 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References