Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4600075..4600661 Replicon chromosome
Accession NZ_CP047537
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag DXN32_RS22640 Protein ID WP_001521773.1
Coordinates 4600075..4600443 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag DXN32_RS22645 Protein ID WP_001520924.1
Coordinates 4600440..4600661 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS22620 (4595635) 4595635..4596705 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
DXN32_RS22625 (4596707) 4596707..4597552 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
DXN32_RS22630 (4597549) 4597549..4598436 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
DXN32_RS22635 (4598500) 4598500..4599816 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
DXN32_RS22640 (4600075) 4600075..4600443 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DXN32_RS22645 (4600440) 4600440..4600661 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN32_RS22650 (4600793) 4600793..4601506 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
DXN32_RS22655 (4601508) 4601508..4602275 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
DXN32_RS22660 (4602272) 4602272..4603549 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
DXN32_RS22665 (4603546) 4603546..4604472 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
DXN32_RS22670 (4604532) 4604532..4605641 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4594898..4605641 10743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T146504 WP_001521773.1 NZ_CP047537:c4600443-4600075 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T146504 NZ_CP062755:4826459-4826800 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT146504 WP_001520924.1 NZ_CP047537:c4600661-4600440 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT146504 NZ_CP062755:c4826464-4826388 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References