Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 312517..313103 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name doc Uniprot ID A0A0R9MYB2
Locus tag PQP93_RS01430 Protein ID WP_000174966.1
Coordinates 312735..313103 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0R9PI96
Locus tag PQP93_RS01425 Protein ID WP_001535398.1
Coordinates 312517..312738 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS01400 (307537) 307537..308646 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PQP93_RS01405 (308706) 308706..309632 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PQP93_RS01410 (309629) 309629..310906 + 1278 WP_274890205.1 branched chain amino acid ABC transporter permease LivM -
PQP93_RS01415 (310903) 310903..311670 + 768 WP_274890206.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PQP93_RS01420 (311672) 311672..312385 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
PQP93_RS01425 (312517) 312517..312738 + 222 WP_001535398.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP93_RS01430 (312735) 312735..313103 + 369 WP_000174966.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PQP93_RS01435 (313362) 313362..314676 + 1315 Protein_282 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
PQP93_RS01440 (314781) 314781..315668 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
PQP93_RS01445 (315665) 315665..316510 + 846 WP_274890207.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
PQP93_RS01450 (316513) 316513..317583 + 1071 WP_000907845.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 309629..318320 8691
- inside Prophage - - 310903..318320 7417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13629.91 Da        Isoelectric Point: 6.4657

>T270955 WP_000174966.1 NZ_CP117380:312735-313103 [Salmonella enterica subsp. enterica serovar Newport]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8165.23 Da        Isoelectric Point: 6.4643

>AT270955 WP_001535398.1 NZ_CP117380:312517-312738 [Salmonella enterica subsp. enterica serovar Newport]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9MYB2

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PI96

References