Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4460470..4461056 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag INN79_RS22120 Protein ID WP_001521773.1
Coordinates 4460470..4460838 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag INN79_RS22125 Protein ID WP_001520924.1
Coordinates 4460835..4461056 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS22100 (4456030) 4456030..4457100 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
INN79_RS22105 (4457102) 4457102..4457947 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
INN79_RS22110 (4457944) 4457944..4458831 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
INN79_RS22115 (4458895) 4458895..4460211 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
INN79_RS22120 (4460470) 4460470..4460838 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
INN79_RS22125 (4460835) 4460835..4461056 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN79_RS22130 (4461188) 4461188..4461901 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
INN79_RS22135 (4461903) 4461903..4462670 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
INN79_RS22140 (4462667) 4462667..4463944 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
INN79_RS22145 (4463941) 4463941..4464867 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
INN79_RS22150 (4464927) 4464927..4466036 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4455293..4463944 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T233743 WP_001521773.1 NZ_CP091558:c4460838-4460470 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T233743 NZ_LN649259:518928-519278 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT233743 WP_001520924.1 NZ_CP091558:c4461056-4460835 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT233743 NZ_LN649259:518642-518923 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References