Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4624075..4624661 Replicon chromosome
Accession NZ_CP047522
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag DXN15_RS22645 Protein ID WP_001521773.1
Coordinates 4624075..4624443 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag DXN15_RS22650 Protein ID WP_001520924.1
Coordinates 4624440..4624661 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS22625 (4619635) 4619635..4620705 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
DXN15_RS22630 (4620707) 4620707..4621552 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
DXN15_RS22635 (4621549) 4621549..4622436 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
DXN15_RS22640 (4622500) 4622500..4623816 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
DXN15_RS22645 (4624075) 4624075..4624443 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DXN15_RS22650 (4624440) 4624440..4624661 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN15_RS22655 (4624793) 4624793..4625506 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
DXN15_RS22660 (4625508) 4625508..4626275 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
DXN15_RS22665 (4626272) 4626272..4627549 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
DXN15_RS22670 (4627546) 4627546..4628472 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
DXN15_RS22675 (4628532) 4628532..4629641 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4618898..4629641 10743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T146349 WP_001521773.1 NZ_CP047522:c4624443-4624075 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T146349 NZ_CP062742:c3584718-3584563 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT146349 WP_001520924.1 NZ_CP047522:c4624661-4624440 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT146349 NZ_CP062742:3584730-3584788 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References