Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4474868..4475454 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag L4413_RS22175 Protein ID WP_001521773.1
Coordinates 4474868..4475236 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag L4413_RS22180 Protein ID WP_001520924.1
Coordinates 4475233..4475454 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS22155 (4470428) 4470428..4471498 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
L4413_RS22160 (4471500) 4471500..4472345 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
L4413_RS22165 (4472342) 4472342..4473229 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
L4413_RS22170 (4473293) 4473293..4474609 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
L4413_RS22175 (4474868) 4474868..4475236 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L4413_RS22180 (4475233) 4475233..4475454 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L4413_RS22185 (4475586) 4475586..4476299 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
L4413_RS22190 (4476301) 4476301..4477068 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
L4413_RS22195 (4477065) 4477065..4478342 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
L4413_RS22200 (4478339) 4478339..4479265 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
L4413_RS22205 (4479325) 4479325..4480434 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4469691..4478342 8651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T233668 WP_001521773.1 NZ_CP091547:c4475236-4474868 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T233668 NZ_LM993812:c1256062-1255955 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT233668 WP_001520924.1 NZ_CP091547:c4475454-4475233 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT233668 NZ_LM993812:1256109-1256175 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References