238374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 298293..298879 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name doc Uniprot ID A0A5T8GXT3
Locus tag MOV19_RS01385 Protein ID WP_000174961.1
Coordinates 298511..298879 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8F2ZY79
Locus tag MOV19_RS01380 Protein ID WP_001599562.1
Coordinates 298293..298514 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS01355 (293313) 293313..294422 + 1110 WP_238727984.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
MOV19_RS01360 (294482) 294482..295408 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MOV19_RS01365 (295405) 295405..296682 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
MOV19_RS01370 (296679) 296679..297446 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MOV19_RS01375 (297448) 297448..298161 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MOV19_RS01380 (298293) 298293..298514 + 222 WP_001599562.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOV19_RS01385 (298511) 298511..298879 + 369 WP_000174961.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MOV19_RS01390 (299137) 299137..300453 + 1317 WP_000624742.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MOV19_RS01395 (300558) 300558..301445 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MOV19_RS01400 (301442) 301442..302287 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MOV19_RS01405 (302290) 302290..303360 + 1071 WP_000907842.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 295405..304097 8692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13589.90 Da        Isoelectric Point: 6.7252

>T238374 WP_000174961.1 NZ_CP093390:298511-298879 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTLGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T238374 NZ_LR890326:c1158750-1158532 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.20 Da        Isoelectric Point: 6.4643

>AT238374 WP_001599562.1 NZ_CP093390:298293-298514 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Download         Length: 222 bp

>AT238374 NZ_LR890326:c1159150-1158776 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACTTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTCCAAAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8GXT3

Antitoxin

Source ID Structure

References