Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 312165..312751 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name doc Uniprot ID Q57IR9
Locus tag A7S33_RS01425 Protein ID WP_000174963.1
Coordinates 312383..312751 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag A7S33_RS01420 Protein ID WP_001522145.1
Coordinates 312165..312386 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS01395 (307186) 307186..308295 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
A7S33_RS01400 (308355) 308355..309281 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
A7S33_RS01405 (309278) 309278..310555 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
A7S33_RS01410 (310552) 310552..311319 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
A7S33_RS01415 (311321) 311321..312034 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
A7S33_RS01420 (312165) 312165..312386 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7S33_RS01425 (312383) 312383..312751 + 369 WP_000174963.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
A7S33_RS01430 (313010) 313010..314326 + 1317 WP_023227921.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
A7S33_RS01435 (314431) 314431..315318 + 888 WP_000094074.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
A7S33_RS01440 (315315) 315315..316160 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
A7S33_RS01445 (316162) 316162..317232 + 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 309278..317969 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13573.85 Da        Isoelectric Point: 6.7252

>T203154 WP_000174963.1 NZ_CP075132:312383-312751 [Salmonella enterica subsp. enterica serovar Inverness]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T203154 NZ_CP099886:4013082-4013360 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGTAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT203154 WP_001522145.1 NZ_CP075132:312165-312386 [Salmonella enterica subsp. enterica serovar Inverness]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT203154 NZ_CP099886:4013360-4013644 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTAACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6KCD5

Antitoxin

Source ID Structure

References