SecReT6, T6SS database

Yersiniaceae

Experimental investigation has been performed.

Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS00929	i3	Serratia marcescens subsp. marcescens Db11	chromosome I (HG326223)	2365124..2402670	anti-bacterial
T6SS00225	i3	Yersinia pseudotuberculosis IP 31758	chromosome (NC_009708)	3850633..3874248	-
T6SS00260	i3	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3905709..3929297	effector translocation
T6SS00017	i3	Yersinia pestis CO92	chromosome (NC_003143)	526127..562682	anti-eukaryotic; virulence
T6SS01033	i3	Serratia sp. FS14	chromosome (NZ_CP005927)	2830818..2854234	-
T6SS01264	i3	Serratia marcescens RM66262	chromosome (NZ_JWLO01000001)	563798..601203	anti-bacterial
T6SS00258	i3	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1619849..1653371	anti-bacterial
T6SS17504	i3	Serratia marcescens strain KZ11	chromosome (NZ_PQGJ01000003)	455631..479047	-
T6SS17505	i3	Serratia marcescens strain KZ11	chromosome (NZ_PQGJ01000003)	580953..617916	anti-bacterial

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0003	RT90_01105 (rcsC)	T6SS01264	protein	TCS-HK	Serratia marcescens strain RM66262	chromosome (JWLO01000001)	232638..235499 (+)	735006326	RT90_01115 (rcsB) (↑)
REG0004	RT90_01115 (rcsB)	T6SS01264	protein	TCS-RR	Serratia marcescens strain RM66262	chromosome (JWLO01000001)	235561..236211 (-)	735006328	vgrG promoter (↓)
REG0005	RT90_16255 (wecG)	T6SS01264	protein	TCS regulatory pathway	Serratia marcescens strain RM66262	chromosome (JWLO01000003)	92056..92796 (-)	735005313	RT90_01105 (rcsC) (↑)
REG0006	L085_RS13655 (ppka)	T6SS01033	protein	Tpp	Serratia sp. FS14	chromosome (NZ_CP005927)	3028273..3029718 (-)	763151328	Unknown (↓)
REG0014	SMDB11_2275 (PpKA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2399154..2400599 (+)	560174118	SMDB11_2267 (FHA) (↓)
REG0015	SMDB11_2268 (PppA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2390232..2391005 (+)	560174111	SMDB11_2267 (FHA) (↑)
REG0016	SMDB11_2269 (RtkS)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2391034..2392020 (+)	560174112	SMDB11_2275 (PpKA) (↓)
REG0017	SMDB11_2256 (TagF)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2380702..2381421 (+)	560174099	Unknown (↑)
REG0185	YpsIP31758_3980 (ompR)	T6SS00225	protein	TCS-RR	Yersinia pseudotuberculosis IP 31758	chromosome (NC_009708)	4465260..4465979 (-)	490527984	T6SS-4 promoter (↓)
REG0186	YpsIP31758_3441 (lptD)	T6SS00225	protein	Unknown	Yersinia pseudotuberculosis IP 31758	chromosome (NC_009708)	3878499..3880841 (+)	499505072	YpsIP31758_3980 (ompR) (↓)
REG0187	YPK_3449 (RelA)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3783755..3785989 (-)	488138165	YPK_1551 (RovM) (↓); YPK_1876 (RovA) (↓)
REG0188	YPK_1876 (RovA)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	2082384..2082815 (+)	488139747	T6SS-4 promoter region (↓); T6SS-4 promoter region (↓)
REG0189	YPK_4079 (OxyR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	4502978..4503895 (-)	488138270	T6SS-4 promoter region (↓)
REG0190	ypk_3425 (RpoS)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3759239..3760237 (-)	499505140	T6SS-4 promoter region (↓)
REG0191	YPK_1551 (RovM)	T6SS00260	protein	(p)ppGpp regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1713682..1714884 (-)	499506038	T6SS-4 promoter region (↓)
REG0192	YPK_3567 (RovC)	T6SS00260	protein	carbon storage regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3929654..3930397 (+)	170025782	YPK_3567 promotor (↓)
REG0193	YPK_3372 (CsrA)	T6SS00260	protein	carbon storage regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3698608..3698793 (-)	169752121	YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0194	YPK_2462 (HpaR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	2695107..2695574 (+)	169751221	T6SS4 promoter (↓)
REG0195	YPK_RS08345 (YpsR)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1837676..1838413 (+)	488140651	T6SS transcripts (↓)
REG0196	YPK_RS03965 (YtbR)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	900476..901219 (+)	488140447	T6SS transcripts (↓)
REG0197	YPK_RS08350 (ypsI)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1838406..1839050 (-)	501053391	T6SS transcripts (↓)
REG0198	YPK_RS03970 (ytbI)	T6SS00256 ; T6SS00260	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	901200..901850 (-)	488144695	T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0199	YPK_RS00840 (OmpR)	T6SS00260	protein	TCS-RR	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	223260..223979 (+)	488137706	T6SS4 promoter (↓)
REG0200	YPK_RS01520 (ZntR)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	333471..333896 (+)	488144494	T6SS4 promoter (↓)
REG0348	SMDB11_2275 (PpkA)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2399154..2400599 (+)	560174118	SMDB11_2267/SMA2267 (Fha) (↓); SMDB11_2267/SMA2267 (Fha) (↑)
REG0349	SMDB11_2267 (Fha)	T6SS00929	protein	Tpp	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2388490..2390232 (+)	560174110	Unknown (↓)
REG0366	YPK_RS19410 (Zur)	T6SS00260	protein	Global regulator	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	4251751..4252260 (+)	488143439	T6SS4 transcription (↓)

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01503	SMDB11_1112 (Ssp3)	Tme	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1178412..1178963 (+)	560172958
EFF01506	SMDB11_4673 (Ssp6)	Tme	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	5022150..5022797 (-)	560176492
EFF01514	SMDB11_1083 (Tfe2)	Tme	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1147856..1148536 (+)	560172929
EFF01495	Spro_3017 (Tre1)	Tre	IMU00317 ; IMU00330 ; IMU00331 ; IMU00332	T6SS00234	Serratia proteamaculans 568	chromosome (NC_009832)	3321185..3322519 (+)	157371257
EFF01836	SMDB11_0810	Tme	IMU00354	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	838784..839398 (-)	560172663
EFF01502	SMDB11_2261 (Ssp1)	Tae	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2385090..2385581 (+)	560174104
EFF01510	SMDB11_2264 (ssp2)	Tae	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2386769..2387245 (+)	560174107
EFF01499	SMDB11_1610 (Rhs2)	Tde	IMU00320	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1689650..1693942 (+)	560173453
EFF01873	YPK_RS04780	Tde	-	T6SS00258	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1067938..1069470 (+)	499506274
EFF01874	YPK_0954 (Tce1)	Tde	IMU00376	T6SS00258	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1069948..1070205 (+)	488156855
EFF01501	SMDB11_0927 (Slp)	Tle	IMU00316 ; IMU00318	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	971234..972886 (+)	560172775
EFF01462	YPK_RS17835	Tie	-	T6SS00260	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3905334..3905687 (-)	169752298
EFF01500	SMDB11_2278 (Rhs1)	Tse	IMU00319	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2403168..2407589 (+)	560174121
EFF01504	SMDB11_3980 (Ssp4)	Tse	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	4242848..4243843 (-)	560175802
EFF01505	SMDB11_4628 (Ssp5)	Tse	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	4979889..4980716 (+)	560176449
EFF01515	SMDB11_1610 (Rhs2)	Tse	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1693944..1694432 (+)	560173454
EFF01516	SMDB11_2278 (Rhs1)	Tse	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2407591..2408079 (+)	560174122
EFF00321	YPK_RS17880	-	-	T6SS00260	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3917120..3919468 (-)	170025773
EFF00322	YPK_RS17905	-	-	T6SS00260	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3925548..3926066 (-)	170025778
EFF01507	SMDB11_3455 (Hcp)	-	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	3668310..3668792 (+)	560175282
EFF01508	SMDB11_3456 (Hcp)	-	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	3668840..3669322 (+)	560175283
EFF01509	SMDB11_2263 (Hcp)	-	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2386232..2386714 (+)	560174106
EFF01512	SMDB11_2244 (VgrG)	-	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2365103..2367463 (+)	560174087
EFF01513	SMDB11_2276 (VgrG)	-	-	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2400742..2402670 (+)	560174119
EFF76649	YPK_3548 (TssS)	Tie	-	T6SS00260	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3905041..3905187 (-)	-

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector
IMU00316	SMDB11_0928	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	972883..973656 (+)	560172776	EFF01501
IMU00317	Spro_3018 (Tri1)	T6SS00234	Serratia proteamaculans 568	chromosome (NC_009832)	3322516..3323616 (+)	501095675	EFF01495
IMU00318	SMDB11_0929	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	973746..974489 (+)	560172777	EFF01501
IMU00319	SMDB11_2278A (RhsI1)	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2407591..2408079 (+)	560174122	EFF01500
IMU00320	SMDB11_1611 (RhsI2)	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1693944..1694432 (+)	560173454	EFF01499
IMU00354	SMDB11_0809	T6SS00929	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	838572..838787 (-)	560172662	EFF01836
IMU00376	YPK_0955 (Tci1)	T6SS00260	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1070252..1070536 (+)	499506273	EFF01874

Experimental investigation has been performed.

Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function
RSF000050	SMDB11_4101 (DsbA1)	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	4377737..4378360 (-)	560175924	sensitive	Effector activator
RSF000051	SMDB11_0239 (DsbA2)	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	265001..265642 (+)	560172104	sensitive	Effector activator

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector
ACP00014	YPK_0782 (btuB)	T6SS00258	chaperone	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1069948..1070205 (+)	488156855	-	YPK_0954 (Tce1)
ACP00015	YPK_2649 (ompF)	T6SS00258	chaperone	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	2911078..2912160 (+)	501261276	-	YPK_0954 (Tce1)
ACP00016	YPK_2956 (tonB)	T6SS00258	chaperone	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	3254339..3255631 (-)	488139530	-	YPK_0954 (Tce1)
ACP00028	SMDB11_4101 (dsbA1)	T6SS00929	chaperone	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	4377737..4378360 (-)	560175924	SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269	SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2)
ACP00029	SMDB11_0239 (dsbA2)	T6SS00929	chaperone	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	265001..265642 (+)	560172104	SMDB11_2255 (TssM); SMDB11_2251; SMDB11_2269	SMDB11_3980 (Ssp4); SMDB11_2264 (Ssp2)
ACP00030	SMDB11_1609 (eagR2)	T6SS00929	adaptor	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	1689187..1689618 (+)	560173452	SMDB11_2276 (VgrG2b)	SMDB11_1610 (Rhs2)
ACP00031	SMDB11_2245 (eagR1)	T6SS00929	adaptor	Serratia marcescens subsp. marcescens Db11	chromosome (HG326223)	2367474..2367863 (+)	560174088	SMDB11_2276 (VgrG2b)	SMDB11_2278 (Rhs1)