Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2828320..2828876 Replicon chromosome
Accession NC_003919
Organism Xanthomonas axonopodis pv. citri str. 306

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag XAC_RS12345 Protein ID WP_011051576.1
Coordinates 2828320..2828610 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M4UBZ0
Locus tag XAC_RS12350 Protein ID WP_004541313.1
Coordinates 2828598..2828876 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XAC_RS25605 2823631..2823771 - 141 WP_157860651.1 hypothetical protein -
XAC_RS26110 (XAC2422) 2824057..2825013 - 957 WP_011051571.1 hypothetical protein -
XAC_RS12320 (XAC2423) 2825080..2826213 - 1134 Protein_2414 IS5 family transposase -
XAC_RS12325 (XAC2424) 2826253..2827340 - 1088 Protein_2415 IS3 family transposase -
XAC_RS12335 2827553..2827732 - 180 WP_015463309.1 hypothetical protein -
XAC_RS12340 2828003..2828317 - 315 WP_015463310.1 hypothetical protein -
XAC_RS12345 (XAC2428) 2828320..2828610 - 291 WP_011051576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XAC_RS12350 (XAC2429) 2828598..2828876 - 279 WP_004541313.1 CopG family ribbon-helix-helix protein Antitoxin
XAC_RS12355 (XAC2430) 2829046..2830314 - 1269 Protein_2420 transposase -
XAC_RS12365 (XAC2432) 2830363..2831588 + 1226 Protein_2421 IS3 family transposase -
XAC_RS12370 (XAC2433) 2832206..2833162 + 957 WP_197707729.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2820490..2847010 26520
inside IScluster/Tn - - 2825080..2831588 6508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10831.41 Da        Isoelectric Point: 9.9308

>T20720 WP_011051576.1 NC_003919:c2828610-2828320 [Xanthomonas citri pv. citri str. 306]
MPQVIFAPAAIGDMQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Download         Length: 291 bp

>T20720 NC_003919:c2828610-2828320 [Xanthomonas citri pv. citri str. 306]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGA
TGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10810.11 Da        Isoelectric Point: 4.9736

>AT20720 WP_004541313.1 NC_003919:c2828876-2828598 [Xanthomonas citri pv. citri str. 306]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Download         Length: 279 bp

>AT20720 NC_003919:c2828876-2828598 [Xanthomonas citri pv. citri str. 306]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M4UBZ0

References