Detailed information of TA system TA169677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2885964..2886520
• Replicon: chromosome
• Accession: NZ_CP060002
• Organism: Xanthomonas citri pv. citri strain SN3-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HZS91_RS12575
• Protein ID: WP_230598886.1
• Coordinates: 2885964..2886215 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: HZS91_RS12580
• Protein ID: WP_004541313.1
• Coordinates: 2886242..2886520 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS91_RS12550 (HZS91_02645)	2881701..2882657	-	957	WP_011051571.1	hypothetical protein	-
HZS91_RS12555 (HZS91_02646)	2882724..2883857	-	1134	Protein_2460	IS5 family transposase	-
HZS91_RS12565 (HZS91_02648)	2885197..2885451	-	255	WP_223293127.1	hypothetical protein	-
HZS91_RS22805	2885520..2885654	-	135	WP_011051575.1	hypothetical protein	-
HZS91_RS12570 (HZS91_02649)	2885647..2885961	-	315	WP_015463310.1	hypothetical protein	-
HZS91_RS12575 (HZS91_02650)	2885964..2886215	-	252	WP_230598886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS91_RS12580 (HZS91_02651)	2886242..2886520	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
HZS91_RS12585 (HZS91_02652)	2886690..2887958	-	1269	Protein_2467	Tn3 family transposase	-
HZS91_RS12590 (HZS91_02653)	2888007..2889232	+	1226	Protein_2468	IS3 family transposase	-
HZS91_RS12595 (HZS91_02654)	2889869..2890576	+	708	Protein_2469	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 Genomic island TA020720 2820490..2847010 0.001	inside	Genomic island	-	-	2878134..2905854	27720
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 IScluster/Tn TA020720 2825080..2831588 0	inside	IScluster/Tn	-	-	2882724..2889232	6508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9519.85 Da
• Isoelectric Point: 10.2314

>T169677 WP_230598886.1 NZ_CP060002:c2886215-2885964 [Xanthomonas citri pv. citri]
MQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169677 NZ_CP076654:2434010-2435332 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT169677 WP_004541313.1 NZ_CP060002:c2886520-2886242 [Xanthomonas citri pv. citri]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169677 NZ_CP076654:2433744-2434010 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0