Detailed information of TA system TA170434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2448047..2448603
• Replicon: chromosome
• Accession: NZ_CP060460
• Organism: Xanthomonas citri pv. citri strain DAR84832

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H8Z70_RS10445
• Protein ID: WP_011051576.1
• Coordinates: 2448047..2448337 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: H8Z70_RS10450
• Protein ID: WP_004541313.1
• Coordinates: 2448325..2448603 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8Z70_RS10420	2443784..2444740	-	957	WP_011051571.1	hypothetical protein	-
H8Z70_RS10425	2444807..2445940	-	1134	Protein_2044	IS5 family transposase	-
H8Z70_RS10430	2445980..2447067	-	1088	Protein_2045	IS3 family transposase	-
H8Z70_RS10435	2447280..2447459	-	180	WP_015463309.1	hypothetical protein	-
H8Z70_RS10440	2447730..2448044	-	315	WP_015463310.1	hypothetical protein	-
H8Z70_RS10445	2448047..2448337	-	291	WP_011051576.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H8Z70_RS10450	2448325..2448603	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
H8Z70_RS10455	2448773..2450041	-	1269	Protein_2050	transposase	-
H8Z70_RS10460	2450090..2451315	+	1226	Protein_2051	IS3 family transposase	-
H8Z70_RS10465	2451934..2452890	+	957	WP_197707729.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2438233..2459710	21477
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 IScluster/Tn TA020720 2825080..2831588 0	inside	IScluster/Tn	-	-	2444807..2451315	6508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10831.41 Da
• Isoelectric Point: 9.9308

>T170434 WP_011051576.1 NZ_CP060460:c2448337-2448047 [Xanthomonas citri pv. citri]
MPQVIFAPAAIGDMQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T170434 NZ_CP077368:233403-233873 [Pantoea agglomerans]
ATGGAAGACAGCACGGTTATAAATGGATGGCACGTTTATGTTCATCCCTGTTTTGAATCGCAGCTGATTGCGCTGACCAA
TGAAGTGGAGTTACTCAGGGCTAAATATCCTGAAAGTTACCAGCGAAAAGCGACGACTAAGCTTTTAGCCGCTGTGTTTA
AAGTTATCAATAGTGAGATTTGCGCCGATCCACATCAGGCAAAGTTTCGCCAGGGCGATACGCTGGGAGAACAAAATAAG
CATTGGTTCCGTGCAAAGTTTTTGATGCAGTATCGTTTGTTCTTTAGATTCAGCGAGCAACATAAAACCATCATCCTTGC
ATGGATGAATGACGCTGAGACCAAACGTGCTTATGGCAGTATGCGTGACGCCTATAAAGTATTTTCAGGAATGTTGCATA
ACGGCTATCCACCTGACGACTGGGCATTGCTGTTAAAGCAATCTCAGGATTGGGCGAAGATAAATTCTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT170434 WP_004541313.1 NZ_CP060460:c2448603-2448325 [Xanthomonas citri pv. citri]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT170434 NZ_CP077368:233052-233396 [Pantoea agglomerans]
ATGGGAACTTTGACTCATGCAAACATCTCTCTGCGTGCTTCATCAAAACTGACAGCCCGCAGCCAGACCACTATCCCTGC
CGCAGTTCGTGATGCGATGAATCTGCAACCTGGTGAGAATATCGAATACGCTGTTCTGCCGGGCGGCAAAGTCCTTATTA
CCCGTCAGGAAACGGTGACTGATGATGATCCAGTGATGGCGAGCTTTCTGAGTTTTCTTGCTGCTGACATACGCAACACA
CCTGCAAATATTAAAACGCTGGATCGAGGATTATTAACTCGCATTACATCGTTGACCGAAGGTATGGACGTTGATTTGGA
TGCTCCACTCATGGACGATGAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0