Detailed information of TA system TA170448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2247808..2248364
• Replicon: chromosome
• Accession: NZ_CP060470
• Organism: Xanthomonas citri pv. citri strain DAR73889

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H8Z72_RS09770
• Protein ID: WP_011051576.1
• Coordinates: 2248074..2248364 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: H8Z72_RS09765
• Protein ID: WP_004541313.1
• Coordinates: 2247808..2248086 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8Z72_RS09750	2243521..2244477	-	957	WP_197707729.1	recombinase family protein	-
H8Z72_RS09755	2245096..2246321	-	1226	Protein_1903	IS3 family transposase	-
H8Z72_RS09760	2246370..2247638	+	1269	Protein_1904	transposase	-
H8Z72_RS09765	2247808..2248086	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
H8Z72_RS09770	2248074..2248364	+	291	WP_011051576.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H8Z72_RS09775	2248367..2248681	+	315	WP_015463310.1	hypothetical protein	-
H8Z72_RS09780	2248952..2249131	+	180	WP_015463309.1	hypothetical protein	-
H8Z72_RS09785	2249344..2250431	+	1088	Protein_1909	IS3 family transposase	-
H8Z72_RS09790	2250471..2251604	+	1134	Protein_1910	IS5 family transposase	-
H8Z72_RS09795	2251671..2252627	+	957	WP_011051571.1	hypothetical protein	-
H8Z72_RS09800	2252913..2253053	+	141	WP_157860651.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 Genomic island TA020720 2820490..2847010 0.006	inside	Genomic island	-	-	2227706..2258178	30472
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 IScluster/Tn TA020720 2825080..2831588 0.001	inside	IScluster/Tn	-	-	2245096..2251604	6508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10831.41 Da
• Isoelectric Point: 9.9308

>T170448 WP_011051576.1 NZ_CP060470:2248074-2248364 [Xanthomonas citri pv. citri]
MPQVIFAPAAIGDMQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T170448 NZ_CP077388:c535223-534762 [Providencia rettgeri]
ATGATTTTATATCGTTTGATTAAATCTGACTTTGCTCATGATGCGTGGTCCGGTCAAGGTGCTAGGTTATACGGTGGGCG
CTGGAACCATAAAGGTACGCCCGCTATCTACACATCAACAAGTATTTCATTAGCTGCTTTAGAAATTCTCGTTCATATAA
ACCAAGATACCGTGCTTAATCATTTCACTTTATTATCAATTGAGATCAACGATAGGTATGTGATGAAGCTGTCAGTAGAG
CATCTCCCTGATGATTGGCAGCGTGACCCAGCACCTACCTCTACAATGGACATAGGCACAACCTGGTTAACTAACCAAGA
CAGCCTAGCCTTAATTGTCCCTTCTTGTATTATTCCTTATGAATATAATGCCATTATTAACCCTATGCACCCGCAATTTC
AAAAAGTGACCCAAACCATTAAGCCCCTCGACTTTGCTTTTGACCCACGATTTAACCGGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT170448 WP_004541313.1 NZ_CP060470:2247808-2248086 [Xanthomonas citri pv. citri]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT170448 NZ_CP077388:c535681-535220 [Providencia rettgeri]
ATGAGAAACTATATTCCAGCACTCCCAACCCAACCCGCCACGCCACCTTTTAAGCCCCTATGGCGCTTTGCTGGCCTACC
CGCAGAACGTGGTATCGAACTCACTCATTTCCTACGACAAGGTCTTTCCGTTACGGTGTTAGACAACATTCAAGAATGGT
CTGGCATCAGCAAATCTGAATTACTCCGTATTTCAGGTATTAATGAGCGCAATGTGGCAAGGCGTAGAAATGCAGGTCAG
CCACTCAATGCCGATGAAAGTGAAAGAATTGCTCGCTTAGTGCGTGTATTTGATGCCGCTGTACGCTTATTCAATGGTGA
TAAGTCAATGGCAAGTGATTGGTTGAATCACCCCGTGAAAGGCTTAGGACATACGCGCCCCATAGAGTTGATTGCCACGG
AAAGTGGTGCTCTTGAAGTTATCGACCTTATTGGCCGCATTGAACACGGTGTTTTTTCATGA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0