Detailed information of TA system TA203456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2893779..2894335
• Replicon: chromosome
• Accession: NZ_CP075325
• Organism: Xanthomonas citri pv. citri strain GD82

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KJA71_RS12830
• Protein ID: WP_230598886.1
• Coordinates: 2893779..2894030 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: KJA71_RS12835
• Protein ID: WP_004541313.1
• Coordinates: 2894057..2894335 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA71_RS12805 (KJA71_12805)	2889516..2890472	-	957	WP_011051571.1	hypothetical protein	-
KJA71_RS12810 (KJA71_12810)	2890539..2891672	-	1134	Protein_2512	IS5 family transposase	-
KJA71_RS12820 (KJA71_12820)	2893012..2893266	-	255	WP_223293127.1	hypothetical protein	-
KJA71_RS24750	2893335..2893469	-	135	WP_011051575.1	hypothetical protein	-
KJA71_RS12825 (KJA71_12825)	2893462..2893776	-	315	WP_015463310.1	hypothetical protein	-
KJA71_RS12830 (KJA71_12830)	2893779..2894030	-	252	WP_230598886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KJA71_RS12835 (KJA71_12835)	2894057..2894335	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
KJA71_RS12840 (KJA71_12840)	2894505..2895773	-	1269	Protein_2519	Tn3 family transposase	-
KJA71_RS12845 (KJA71_12845)	2895822..2897047	+	1226	Protein_2520	IS3 family transposase	-
KJA71_RS12850 (KJA71_12850)	2897683..2898390	+	708	Protein_2521	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 Genomic island TA020720 2820490..2847010 0	inside	Genomic island	-	-	2885949..2912469	26520
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003919 Xanthomonas axonopodis pv. citri str. 306 IScluster/Tn TA020720 2825080..2831588 0	inside	IScluster/Tn	-	-	2890539..2897047	6508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9519.85 Da
• Isoelectric Point: 10.2314

>T203456 WP_230598886.1 NZ_CP075325:c2894030-2893779 [Xanthomonas citri pv. citri]
MQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T203456 NZ_CP100094:c2736988-2735666 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT203456 WP_004541313.1 NZ_CP075325:c2894335-2894057 [Xanthomonas citri pv. citri]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT203456 NZ_CP100094:c2737254-2736988 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0