Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2846678..2847234 Replicon chromosome
Accession NZ_CP059992
Organism Xanthomonas citri strain T4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HZS93_RS12480 Protein ID WP_230598886.1
Coordinates 2846678..2846929 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M4UBZ0
Locus tag HZS93_RS12485 Protein ID WP_004541313.1
Coordinates 2846956..2847234 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS93_RS12450 2841989..2842129 - 141 WP_157860651.1 hypothetical protein -
HZS93_RS12455 (HZS93_02619) 2842415..2843371 - 957 WP_011051571.1 hypothetical protein -
HZS93_RS12460 (HZS93_02620) 2843438..2844571 - 1134 Protein_2443 IS5 family transposase -
HZS93_RS12470 (HZS93_02622) 2845911..2846165 - 255 WP_223293127.1 hypothetical protein -
HZS93_RS24620 2846234..2846368 - 135 WP_011051575.1 hypothetical protein -
HZS93_RS12475 (HZS93_02623) 2846361..2846675 - 315 WP_015463310.1 hypothetical protein -
HZS93_RS12480 (HZS93_02624) 2846678..2846929 - 252 WP_230598886.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS93_RS12485 (HZS93_02625) 2846956..2847234 - 279 WP_004541313.1 CopG family ribbon-helix-helix protein Antitoxin
HZS93_RS12490 (HZS93_02626) 2847404..2848672 - 1269 Protein_2450 Tn3 family transposase -
HZS93_RS12495 (HZS93_02627) 2848721..2849946 + 1226 Protein_2451 IS3 family transposase -
HZS93_RS12500 (HZS93_02628) 2850582..2851289 + 708 Protein_2452 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2838848..2865368 26520
inside IScluster/Tn - - 2843438..2849946 6508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-81)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9519.85 Da        Isoelectric Point: 10.2314

>T169646 WP_230598886.1 NZ_CP059992:c2846929-2846678 [Xanthomonas citri]
MQRLREFLKPKSPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Download         Length: 252 bp

>T169646 NZ_CP076647:96977-97129 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10810.11 Da        Isoelectric Point: 4.9736

>AT169646 WP_004541313.1 NZ_CP059992:c2847234-2846956 [Xanthomonas citri]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Download         Length: 279 bp

>AT169646 NZ_CP076647:c96927-96865 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M4UBZ0

References