293162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1604115..1604917 Replicon chromosome
Accession NZ_LT571449
Organism Staphylococcus epidermidis isolate BPH0662

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag BN6763_RS07980 Protein ID WP_002468490.1
Coordinates 1604115..1604294 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag BN6763_RS07985 Protein ID WP_002456349.1
Coordinates 1604318..1604917 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN6763_RS07960 1599508..1600641 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
BN6763_RS07965 1600800..1601624 + 825 WP_001829804.1 RluA family pseudouridine synthase -
BN6763_RS07970 1601985..1603370 - 1386 WP_063964221.1 class II fumarate hydratase -
BN6763_RS07975 1603555..1603959 - 405 WP_001829818.1 hypothetical protein -
BN6763_RS07980 1604115..1604294 - 180 WP_002468490.1 hypothetical protein Toxin
BN6763_RS07985 1604318..1604917 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
BN6763_RS07990 1605075..1605545 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BN6763_RS07995 1605542..1606672 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
BN6763_RS08000 1606882..1607019 - 138 WP_064783702.1 hypothetical protein -
BN6763_RS08005 1607534..1608256 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
BN6763_RS08010 1608249..1609706 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1606882..1607037 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T293162 WP_002468490.1 NZ_LT571449:c1604294-1604115 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T293162 NZ_LT571449:c1604294-1604115 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT293162 WP_002456349.1 NZ_LT571449:c1604917-1604318 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT293162 NZ_LT571449:c1604917-1604318 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References