Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 949620..950422 Replicon chromosome
Accession NZ_CP090998
Organism Staphylococcus epidermidis strain BC1191

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB233_RS04535 Protein ID WP_002468490.1
Coordinates 950243..950422 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB233_RS04530 Protein ID WP_002456349.1
Coordinates 949620..950219 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB233_RS04505 (KB233_04505) 944831..946288 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KB233_RS04510 (KB233_04510) 946281..947003 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB233_RS04515 (KB233_04515) 947500..947655 + 156 WP_001829854.1 hypothetical protein -
KB233_RS04520 (KB233_04520) 947865..948995 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KB233_RS04525 (KB233_04525) 948992..949462 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB233_RS04530 (KB233_04530) 949620..950219 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB233_RS04535 (KB233_04535) 950243..950422 + 180 WP_002468490.1 SAS053 family protein Toxin
KB233_RS04540 (KB233_04540) 950578..950982 + 405 WP_001829818.1 hypothetical protein -
KB233_RS04545 (KB233_04545) 951167..952552 + 1386 WP_001829862.1 class II fumarate hydratase -
KB233_RS04550 (KB233_04550) 952913..953737 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB233_RS04555 (KB233_04555) 953896..955029 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 947500..947655 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232286 WP_002468490.1 NZ_CP090998:950243-950422 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232286 NZ_CP127275:2787419-2787844 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT232286 WP_002456349.1 NZ_CP090998:949620-950219 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232286 NZ_CP127275:2787192-2787413 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References