Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1184865..1185667 Replicon chromosome
Accession NZ_CP093212
Organism Staphylococcus epidermidis strain TSM-51

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU32_RS05890 Protein ID WP_002468490.1
Coordinates 1185488..1185667 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU32_RS05885 Protein ID WP_002456349.1
Coordinates 1184865..1185464 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU32_RS05860 (MNU32_05860) 1180076..1181533 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU32_RS05865 (MNU32_05865) 1181526..1182248 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU32_RS05870 (MNU32_05870) 1182745..1182900 + 156 WP_001829854.1 hypothetical protein -
MNU32_RS05875 (MNU32_05875) 1183110..1184240 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU32_RS05880 (MNU32_05880) 1184237..1184707 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU32_RS05885 (MNU32_05885) 1184865..1185464 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU32_RS05890 (MNU32_05890) 1185488..1185667 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU32_RS05895 (MNU32_05895) 1185823..1186227 + 405 WP_001829818.1 hypothetical protein -
MNU32_RS05900 (MNU32_05900) 1186412..1187797 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU32_RS05905 (MNU32_05905) 1188158..1188982 - 825 WP_254104734.1 RluA family pseudouridine synthase -
MNU32_RS05910 (MNU32_05910) 1189141..1190274 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1182745..1182900 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237807 WP_002468490.1 NZ_CP093212:1185488-1185667 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237807 NZ_LR882967:776289-776573 [Planktothrix pseudagardhii]
ATGCCTCAAAAATATAAAGACAAACGCACAGCCAAATTTGCTGCTGGCGATCGTGTCAAAAAATTTCAGGCATTTGAAAG
ACAAGCATACAAGCGCCTAGAAATCCTAGAAGCCGCACCTAATAAAGAATCCTTAATAGCTTTGCCAAGTAACCATTTTG
AGGCACTAAGTGGAGATAGAAAAGGGCAGTACAGCATCCGCATAAATGATAAATGGCGTATTTGTTTTGAGTGGACAGAA
ACAGAAAATCGTCCATTTAACATCGAAATTGTCGATTATCACTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237807 WP_002456349.1 NZ_CP093212:1184865-1185464 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237807 NZ_LR882967:776588-776902 [Planktothrix pseudagardhii]
ATGGCAAGACCTGCAATTCACCCTGGCGAAATCTTATCTGATGAATTAAAAGAACTGGGAATTAGTGCATCAGAATTAGC
GCGATCGCTCCATATACCCACAAATCGGATTACGCAAATTCTCAAAGGGCAAAGAGGTATTACTGCTGACACGGCATTAC
GTCTAGGACGATGGTTTGGCACGGGTGCAGAACTATGGCTTAATTTGCAAAAAGCTTATGAGTTACGCCTAGCCGAAGAG
TTAGCGGGAGAAGAAATTAAAAAGACGATTCAACCTCGTTCATCTATAAACAATCAGCCGTTAGTTAAAGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References