Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 1184865..1185667 | Replicon | chromosome |
Accession | NZ_CP093212 | ||
Organism | Staphylococcus epidermidis strain TSM-51 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | MNU32_RS05890 | Protein ID | WP_002468490.1 |
Coordinates | 1185488..1185667 (+) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | Q5HN82 |
Locus tag | MNU32_RS05885 | Protein ID | WP_002456349.1 |
Coordinates | 1184865..1185464 (+) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU32_RS05860 (MNU32_05860) | 1180076..1181533 | + | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
MNU32_RS05865 (MNU32_05865) | 1181526..1182248 | + | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
MNU32_RS05870 (MNU32_05870) | 1182745..1182900 | + | 156 | WP_001829854.1 | hypothetical protein | - |
MNU32_RS05875 (MNU32_05875) | 1183110..1184240 | + | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
MNU32_RS05880 (MNU32_05880) | 1184237..1184707 | + | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
MNU32_RS05885 (MNU32_05885) | 1184865..1185464 | + | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
MNU32_RS05890 (MNU32_05890) | 1185488..1185667 | + | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
MNU32_RS05895 (MNU32_05895) | 1185823..1186227 | + | 405 | WP_001829818.1 | hypothetical protein | - |
MNU32_RS05900 (MNU32_05900) | 1186412..1187797 | + | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
MNU32_RS05905 (MNU32_05905) | 1188158..1188982 | - | 825 | WP_254104734.1 | RluA family pseudouridine synthase | - |
MNU32_RS05910 (MNU32_05910) | 1189141..1190274 | + | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 1182745..1182900 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T237807 WP_002468490.1 NZ_CP093212:1185488-1185667 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
>T237807 NZ_LR882967:776289-776573 [Planktothrix pseudagardhii]
ATGCCTCAAAAATATAAAGACAAACGCACAGCCAAATTTGCTGCTGGCGATCGTGTCAAAAAATTTCAGGCATTTGAAAG
ACAAGCATACAAGCGCCTAGAAATCCTAGAAGCCGCACCTAATAAAGAATCCTTAATAGCTTTGCCAAGTAACCATTTTG
AGGCACTAAGTGGAGATAGAAAAGGGCAGTACAGCATCCGCATAAATGATAAATGGCGTATTTGTTTTGAGTGGACAGAA
ACAGAAAATCGTCCATTTAACATCGAAATTGTCGATTATCACTAA
ATGCCTCAAAAATATAAAGACAAACGCACAGCCAAATTTGCTGCTGGCGATCGTGTCAAAAAATTTCAGGCATTTGAAAG
ACAAGCATACAAGCGCCTAGAAATCCTAGAAGCCGCACCTAATAAAGAATCCTTAATAGCTTTGCCAAGTAACCATTTTG
AGGCACTAAGTGGAGATAGAAAAGGGCAGTACAGCATCCGCATAAATGATAAATGGCGTATTTGTTTTGAGTGGACAGAA
ACAGAAAATCGTCCATTTAACATCGAAATTGTCGATTATCACTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT237807 WP_002456349.1 NZ_CP093212:1184865-1185464 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
>AT237807 NZ_LR882967:776588-776902 [Planktothrix pseudagardhii]
ATGGCAAGACCTGCAATTCACCCTGGCGAAATCTTATCTGATGAATTAAAAGAACTGGGAATTAGTGCATCAGAATTAGC
GCGATCGCTCCATATACCCACAAATCGGATTACGCAAATTCTCAAAGGGCAAAGAGGTATTACTGCTGACACGGCATTAC
GTCTAGGACGATGGTTTGGCACGGGTGCAGAACTATGGCTTAATTTGCAAAAAGCTTATGAGTTACGCCTAGCCGAAGAG
TTAGCGGGAGAAGAAATTAAAAAGACGATTCAACCTCGTTCATCTATAAACAATCAGCCGTTAGTTAAAGTTTAG
ATGGCAAGACCTGCAATTCACCCTGGCGAAATCTTATCTGATGAATTAAAAGAACTGGGAATTAGTGCATCAGAATTAGC
GCGATCGCTCCATATACCCACAAATCGGATTACGCAAATTCTCAAAGGGCAAAGAGGTATTACTGCTGACACGGCATTAC
GTCTAGGACGATGGTTTGGCACGGGTGCAGAACTATGGCTTAATTTGCAAAAAGCTTATGAGTTACGCCTAGCCGAAGAG
TTAGCGGGAGAAGAAATTAAAAAGACGATTCAACCTCGTTCATCTATAAACAATCAGCCGTTAGTTAAAGTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HY44 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E9LUD0 |